| Identification | Back Directory | [Name]
Ethanol, 2-[[[3,4-bis(phenylmethoxy)phenyl]methyl]amino]- | [CAS]
500899-98-9 | [Synonyms]
2-((3,4-Bis(benzyloxy)benzyl)amino)ethan-1-ol
Ethanol, 2-[[[3,4-bis(phenylmethoxy)phenyl]methyl]amino]- | [Molecular Formula]
C23H25NO3 | [MDL Number]
MFCD32011809 | [MOL File]
500899-98-9.mol | [Molecular Weight]
363.45 |
| Chemical Properties | Back Directory | [Boiling point ]
550.5±45.0 °C(Predicted) | [density ]
1.155±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
H2O: 2 mg/mL, clear | [form ]
powder | [pka]
14.74±0.10(Predicted) | [color ]
white to beige | [Water Solubility ]
H2O: 2mg/mL, clear | [InChI]
1S/C23H25NO3.ClH/c25-14-13-24-16-21-11-12-22(26-17-19-7-3-1-4-8-19)23(15-21)27-18-20-9-5-2-6-10-20;/h1-12,15,24-25H,13-14,16-18H2;1H | [InChIKey]
ROURICFSUKPJOO-UHFFFAOYSA-N | [SMILES]
OCCNCC1=CC(OCC2=CC=CC=C2)=C(C=C1)OCC3=CC=CC=C3.Cl |
| Hazard Information | Back Directory | [Biological Activity]
XIE62-1004 is a synthetic sequestosome-1 (p62SQSTM1) ZZ domain ligand th at induces disulfide bond-linked and PB1 domain-dependent p62 self-aggregationleading to interaction with LC3 on autophagic membranes and p62/cargoes delivery (2.5-10 μM for 6-24 hrs in p62-expressing HeLa cultures). XIE62-1004 treatment (10 μM18 hrs) effectively reduces insoluble aggregates of transiently expressed mutant huntingtin (mHTT) constructs in HeLa (GFP-HDQ103) and PC12 (EGFP-HDQ74) trransfectantsas well as in wild-typebut not autophagy defective Atg5-/- MEFs (GFP-HDQ103). |
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| Company Name: |
Energy Chemical
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| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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