| Identification | Back Directory | [Name]
BigLEN (mouse) | [CAS]
501036-69-7 | [Synonyms]
BigLEN (mouse)
L-Proline, L-leucyl-L-α-glutamyl-L-asparaginyl-L-prolyl-L-seryl-L-prolyl-L-glutaminyl-L-alanyl-L-prolyl-L-alanyl-L-arginyl-L-arginyl-L-leucyl-L-leucyl-L-prolyl- | [Molecular Formula]
C78H130N24O22 | [MOL File]
501036-69-7.mol | [Molecular Weight]
1756.04 |
| Chemical Properties | Back Directory | [density ]
1.51±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
3.44±0.20(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble to 2 mg/ml in water |
| Hazard Information | Back Directory | [Uses]
BigLEN(mouse) is a potent and selective agonist of orphan G protein-coupled receptor 171 (GPR171), with a Kd of ～0.5 nM. BigLEN(mouse) can be used to regulate responses associated with food intake and metabolism[1][2]. | [storage]
Store at -20°C | [References]
[1] Gomes I, et, al. GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16211-6. DOI:10.1073/pnas.1312938110
[2] Mack SM, et, al. Neuropeptide PEN and Its Receptor GPR83: Distribution, Signaling, and Regulation. ACS Chem Neurosci. 2019 Apr 17;10(4):1884-1891. DOI:10.1021/acschemneuro.8b00559 |
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BOC Sciences
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https://www.bocsci.com |
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