| Identification | Back Directory | [Name]
9-Acridinecarbonitrile, 3,6-diamino- | [CAS]
501935-96-2 | [Synonyms]
CTX1 >=95% (HPLC)
9-Acridinecarbonitrile, 3,6-diamino- | [Molecular Formula]
C14H10N4 | [MOL File]
501935-96-2.mol | [Molecular Weight]
234.26 |
| Chemical Properties | Back Directory | [Boiling point ]
582.5±30.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
6.13±0.10(Predicted) | [color ]
Reddish brown to red |
| Hazard Information | Back Directory | [Uses]
CTX1 is a p53 activator that overcomes HdmX-mediated p53 repression. CTX1 exhibits potent anti-cancer activity in a mouse acute myeloid leukemia (AML) model system[1]. | [in vivo]
CTX1 ( (30 mg/kg; i.p.; five days a week; for 3 weeks) significantly enhances the survival of mice in AML model system[1].
CTX1 exhibited significant anti-cancer activity alone as well as in combination with nutlin-3[1].
| [storage]
Store at -20°C | [References]
[1] Karan G, et al. Identification of a Small Molecule That Overcomes HdmX-Mediated Suppression of p53. Mol Cancer Ther. 2016 Apr;15(4):574-582. DOI:10.1158/1535-7163.MCT-15-0467 |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310; |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|