| Identification | Back Directory | [Name]
Thiazole, 4-methyl-5-[2-[4-(1H-pyrazol-3-yl)phenoxy]ethyl]- | [CAS]
502654-40-2 | [Synonyms]
CYP4A11/CYP4F2-IN-1
Thiazole, 4-methyl-5-[2-[4-(1H-pyrazol-3-yl)phenoxy]ethyl]- | [Molecular Formula]
C15H15N3OS | [MOL File]
502654-40-2.mol | [Molecular Weight]
285.36 |
| Chemical Properties | Back Directory | [Boiling point ]
537.9±50.0 °C(Predicted) | [density ]
1.260±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.48±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CYP4A11/CYP4F2-IN-1 is a potent dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50s of 19 nM and 17 nM, respectively. CYP4A11/CYP4F2-IN-1 has potential for the research of renal diseases[1]. | [IC 50]
CYP4A11: 19 nM (IC50); CYP4F2: 17 nM (IC50) | [References]
[1] Kawamura M, et, al. Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition. J Med Chem. 2022 Nov 10;65(21):14599-14613. DOI:10.1021/acs.jmedchem.2c01089 |
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