| Identification | Back Directory | [Name]
Benzonitrile, 4-[(3,4-dihydro-9-methoxy-4-oxospiro[2H-naphth[2,1-e]-1,3-oxazine-2,4'-piperidin]-1'-yl)methyl]- | [CAS]
503048-34-8 | [Synonyms]
JTK-101
JTK-1011
JTK 101,JTK101
Benzonitrile, 4-[(3,4-dihydro-9-methoxy-4-oxospiro[2H-naphth[2,1-e]-1,3-oxazine-2,4'-piperidin]-1'-yl)methyl]- | [Molecular Formula]
C25H23N3O3 | [MOL File]
503048-34-8.mol | [Molecular Weight]
413.47 |
| Hazard Information | Back Directory | [Uses]
JTK-101 is a selective HIV inhibitor. JTK-101 selectively reduces HIV-1 mRNA synthesis by inhibiting Tat cofactors, including CDK9 and cyclin T1, thereby suppressing the transcriptional activity of HIV-1. JTK-101 may be used in the field of anti-HIV virus research[1]. | [IC 50]
HIV-1; CDK9/cyclinT1 | [References]
[1] Wang X, et al. Potent and selective inhibition of Tat-dependent HIV-1 replication in chronically infected cells by a novel naphthalene derivative JTK-101. Antivir Chem Chemother. 2007;18(4):201-11. DOI:10.1177/095632020701800404 |
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