| Identification | Back Directory | [Name]
7,11,15-trimethyl-3-methylidene-hexadec-1-ene | [CAS]
504-96-1 | [Synonyms]
Hsdb 4321
Neophytadiene
2-(4,8,12-Trimethyltridecyl)-1,3-butadiene
2-(4,8,12-Trimethyltridecyl)buta-1,3-diene
3-Methylene-7,11,15-trimethylhexadec-1-ene
7,11,15-Trimethyl-3-methylene-1-hexadecene
1,3-Butadiene, 2-(4,8,12-trimethyltridecyl)-
1-Hexadecene, 7,11,15-trimethyl-3-methylene-
7,11,15-trimethyl-3-methylidene-hexadec-1-ene | [Molecular Formula]
C20H38 | [MDL Number]
MFCD18252507 | [MOL File]
504-96-1.mol | [Molecular Weight]
278.52 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless Liquid | [Uses]
Enzyme inhibitor.
This product contains up 15% hexanes and up to 5% of the analogous dimer by NMR | [Definition]
ChEBI: Neophytadiene is a diterpene that is 3-methylidenehexadec-1-ene substituted at positions 7, 11 and 15 by a methyl group. It has a role as an anti-inflammatory agent, an antimicrobial agent, a plant metabolite and an algal metabolite. It is an alkene and a diterpene. | [in vivo]
Neophytadiene (50 mg/kg; p.o.; daily; for 7 days) shows dose-dependent reduction in the alanine aminotransferase (ALT) level[1].
Neophytadiene (25-50 mg/kg; p.o.; daily; for 7 days) significantly reduces LPS (10 mg/kg)-increased IL-6 and 1L-10 levels and in heart tissue[1].
Neophytadiene (25-50 mg/kg; p.o.; daily; for 7 days) significantly reduces LPS (10 mg/kg)-increased PGE2 mRNA expression in heart tissue[1].
Neophytadiene significantly inhibits LPS (10 mg/kg)-induced NO production and inflammatory cytokines TNF-α, IL-6 and IL-10 and IL-10 in vivo[1].
| Animal Model: | Adult male Sprague Dawley rats (6-8 weeks)[1] | | Dosage: | 12 mg/kg, 25 mg/kg, 50 mg/kg | | Administration: | Oral administration, daily, for 7 days | | Result: | Decreased haemoglobin (HGB) level, ALT level, and heart tissue TNF-α, IL1β, NF-κB, iNOS, PI3k/AktandMAPK in LPS (10 mg/kg)-treat rats. |
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DKMbiochem.Co. Ltd Gold
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Shureli Biopharma Co.,Ltd Gold
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