| Identification | Back Directory | [Name]
2',3',5',6'-TETRAHYDRO-1'H-[3,4']BIPYRIDINYL-4'-OL | [CAS]
50461-59-1 | [Synonyms]
4-(Pyridin-3-yl)
4-(3-pyridyl)-4-piperidinol
4-(3-pyridyl)piperidin-4-ol
4-PYRIDIN-3-YLPIPERIDIN-4-OL
4-(3-Pyridinyl)-4-piperidinol
4-Piperidinol, 4-(3-pyridinyl)-
4-(3-PYRIDYL)-4-HYDROXYPIPERIDINE
4-HYDROXY-4-PYRID-3-YL(PIPERIDINE)
4-(3-Pyridinyl)-4-piperidinol 2HCl
4-Pyridin-3-ylpiperidin-4-ol dihydrochloride
4-pyridin-3-ylpiperidin-4-ol(SALTDATA: 2HCl H2O)
2',3',5',6'-TETRAHYDRO-1'H-[3,4']BIPYRIDINYL-4'-OL
2',3',5',6'-TETRAHYDRO-1'H-[3,4']BIPYRIDINYL-4'-OL ISO 9001：2015 REACH | [Molecular Formula]
C10H14N2O | [MDL Number]
MFCD04117758 | [MOL File]
50461-59-1.mol | [Molecular Weight]
178.23 |
| Chemical Properties | Back Directory | [Boiling point ]
345.0±42.0 °C(Predicted) | [density ]
1.147±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
13.45±0.20(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 4-hydroxy-4-(3-pyridinyl)piperidine from 1-benzyl-4-(pyridin-3-yl)piperidin-4-ol:
2. A catalytic amount of 10% Pd/C ammonium formate solution (22.7 g, dissolved in 50 ml of water) was added to a solution of methanol (200 ml) of the stage 2 product (32 g) and the mixture was heated at 68 °C overnight. After completion of the reaction, the reaction mixture was filtered using diatomaceous earth and the solvent was removed under vacuum. The residue was washed with acetone (100 ml) to give 17 g of product in 81% yield. | [References]
[1] Patent: US2008/249128, 2008, A1. Location in patent: Page/Page column 47
[2] Patent: US2010/152158, 2010, A1. Location in patent: Page/Page column 30
[3] Patent: US2010/173889, 2010, A1. Location in patent: Page/Page column 59
[4] Patent: US2010/222324, 2010, A1. Location in patent: Page/Page column 53 |
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