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505070-05-3

505070-05-3 Structure

505070-05-3 Structure
IdentificationBack Directory
[Name]

Bid BH3 (80-99)
[CAS]

505070-05-3
[Synonyms]

Bid BH3 (80-99)
[Molecular Formula]

C95H161N33O32S
[MOL File]

505070-05-3.mol
[Molecular Weight]

2309.57
Chemical PropertiesBack Directory
[density ]

1.521±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[Sequence]

Glu-Asp-Ile-Ile-Arg-Asn-Ile-Ala-Arg-His-Leu-Ala-Gln-Val-Gly-Asp-Ser-Met-Asp-Arg
Hazard InformationBack Directory
[Uses]

Bid BH3 (80-99) is a biological active peptide. (BID is a pro-apoptotic member of the 'BH3-only' (BOPS) subset of the BCL-2 family of proteins that constitute a critical control point in apoptosis. Bid is the first of the BOPs reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)
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