| Identification | Back Directory | [Name]
7-METHOXY-2-NAPHTHOL | [CAS]
5060-82-2 | [Synonyms]
7-METHOXY-2-PHTHOL
3-Methoxy-6-naphthol
7-METHOXY-2-NAPHTHOL
7-Methoxy-beta-naphthol
7-methoxynaphthalen-2-ol
7-Methoxy-2-naphthalenol
7-Methoxy-2-naphthol 98%
2-Naphthalenol, 7-methoxy-
2-Hydroxy-7-methoxynaphthalene
7-Methoxy-2-naphthol, 97%, 97% | [Molecular Formula]
C11H10O2 | [MDL Number]
MFCD00075494 | [MOL File]
5060-82-2.mol | [Molecular Weight]
174.2 |
| Chemical Properties | Back Directory | [Melting point ]
116-119 °C(lit.)
| [Boiling point ]
336.7±15.0 °C(Predicted) | [density ]
1.193 | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
Crystalline Powder or Chunks | [pka]
9.45±0.40(Predicted) | [color ]
White to brown | [BRN ]
2207279 | [InChI]
1S/C11H10O2/c1-13-11-5-3-8-2-4-10(12)6-9(8)7-11/h2-7,12H,1H3 | [InChIKey]
UNFNRIIETORURP-UHFFFAOYSA-N | [SMILES]
COc1ccc2ccc(O)cc2c1 |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
26-36 | [WGK Germany ]
3
| [F ]
8-9-23 | [HS Code ]
29071990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
White to brown solid | [Uses]
7-Methoxy-2-naphthol may be used in the synthesis of new 1H-benzo[f]chromene derivatives. It may be used in the synthesis of 7-methoxy-2-naphthyl (MN)-derived xylosides in which the methoxy group served as a marker for NMR characterization and UV detection. | [General Description]
7-Methoxy-2-naphthol is a 7-substituted-2-naphthol. Crystal structure of 7-methoxy-2-naphthol has been reported. Reaction of 7-methoxy-2-naphthol with N-methyl-N-phenylhydrazine under thermal conditions has been reported. | [Synthesis]
General method: a mixture of 2,7-dihydroxynaphthalene (500 mg, 2.64 mmol), dimethyl sulfate (0.5 ml, 5.3 mmol) and potassium carbonate (73.1 mg, 5.3 mmol) in acetonitrile (10 ml) was refluxed for 1 hour. After completion of the reaction, the solvent was removed by evaporation and the residue was poured into water and extracted with ethyl acetate. The organic layer was washed sequentially with water and brine, dried over anhydrous magnesium sulfate and subsequently concentrated under vacuum. The crude product was purified by silica gel column chromatography to afford 7-methoxy-2-naphthol using hexane/ethyl acetate (15:1) as eluent. | [References]
[1] Molecular Pharmacology, 2013, vol. 84, # 5, p. 726 - 735
[2] Patent: US2006/52378, 2006, A1. Location in patent: Page/Page column 112
[3] Journal fuer Praktische Chemie (Leipzig), 1916, vol. <2> 94, p. 25
[4] Journal of medicinal chemistry, 1971, vol. 14, # 11, p. 1023 - 1026 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
| Company Name: |
Heterochem
|
| Telephone: |
027-88041443 13072715837 |
| Website: |
www.hetero-chem.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|