50700-61-3

1064077-34-4

50700-61-3

The general procedure for the synthesis of 3-hydroxy-1-methyl-1H-pyridin-4-one from 1-methyl-3-benzyloxy-4(1H)-pyridinone was as follows: a mixture of 3-benzyloxy-1-methyl-1H-pyridin-4-one (14.1 g, 65.5 mmol) with 10% Pd/C (1.20 g) in methanol was placed in a Parr reactor at 50 psi The hydrogenation reaction was carried out under hydrogen pressure for 70 min. Upon completion of the reaction, the mixture was filtered through a Celite pad and the filtrate was concentrated to dryness. The residue was ground with acetone and the solid product was subsequently collected by filtration. After drying in a vacuum oven, 3-hydroxy-1-methyl-1H-pyridin-4-one was obtained as a light brown powder (7.13 g, 87% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 7.49 (br.s, 1H), 7.38 (s, 1H), 6.12 (br.s, 1H), 3.63 (s, 3H); MS-ESI (m/z): 125.7 [M + 1]+.