| Identification | Back Directory | [Name]
3-nitro-4-hydroxypropiophenone | [CAS]
50916-44-4 | [Synonyms]
3-nitro-4-hydroxypropiophenone
4'-Hydroxy-3'-nitropropiophenone
1-(4-hydroxy-3-nitrophenyl)propan-1-one
1-Propanone, 1-(4-hydroxy-3-nitrophenyl)- | [Molecular Formula]
C9H9NO4 | [MDL Number]
MFCD14552665 | [MOL File]
50916-44-4.mol | [Molecular Weight]
195.17 |
| Hazard Information | Back Directory | [Preparation]
Preparation by treatment of 4-hydroxypropiophenone with fuming nitric acid or with nitric acid in concentrated sulfuric acid between ?2° and 0° (80%)
Preparation by Friedel–Crafts acylation of o-nitrophenol with propionyl chloride in nitrobenzene in the presence of aluminium chloride at 55–60° for 2.5 h, then at r.t. overnight
Also obtained (poor yield) by Fries rearrangement of 2-nitrophenyl propionate in nitrobenzene with aluminium chloride at 90° for 8 h, then at r.t. overnight
Also obtained by reaction of concentrated nitric acid with 2,2′-dihydroxy-5, 5′-dipropionyldiphenyl sulfide (m.p. 103°) in concentrated sulfuric acid at r.t. overnight. |
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