| Identification | Back Directory | [Name]
4-Bromo-2,6-dimethylpyridine | [CAS]
5093-70-9 | [Synonyms]
4-Bromo-2,6-lutidine
4-Bromo-2,6-dimethylpyridine
2.6-Dimethyl-4-bromopyridine
Pyridine, 4-broMo-2,6-diMethyl-
2,6-Dimethyl-4-bromopyridine, >=98%
4-bromo-2,6-dimethylpyridine hydrobromide
4-bromo-2,6-dimethylpyridine(SALTDATA: FREE)
4-Bromo-2,6-dimethylpyridine ISO 9001：2015 REACH | [Molecular Formula]
C7H8BrN | [MDL Number]
MFCD00671475 | [MOL File]
5093-70-9.mol | [Molecular Weight]
186.05 |
| Questions And Answer | Back Directory | [Synthesis]
2,6-Dimethylpyridin-4-ol (3.25 g) in chloroform (40 mL) was treated with phosphorus pentabromide (11.5 g). The reaction mixture was heated to 60°C for 2 hours, and the solvent was removed. The residue was heated to 120°C overnight. The reaction mixture was treated with NaOH (45 g dissolved in 500 mL water), and the product was extracted into EtOAc (3 x 100 mL). The bound organic matter was dried on sodium sulfate and concentrated onto diatomaceous earth. The product, 4-bromo-2,6-dimethylpyridinium, was purified by silica gel chromatography using EtOAc in hexane (0-35%). Yellow oil, yield 2.95 g.
 Figure 4: Synthetic route of 4-Bromo-2,6-dimethylpyridine |
| Chemical Properties | Back Directory | [Melting point ]
28-32°C | [Boiling point ]
194 °C | [density ]
1.415±0.06 g/cm3(Predicted) | [Fp ]
93℃ | [storage temp. ]
2-8°C | [form ]
solid | [pka]
5.41±0.10(Predicted) | [Appearance]
Colorless to off-white <28°C Solid,>32°C Liquid | [InChI]
InChI=1S/C7H8BrN/c1-5-3-7(8)4-6(2)9-5/h3-4H,1-2H3 | [InChIKey]
VTRFAYHJKSKHGY-UHFFFAOYSA-N | [SMILES]
C1(C)=NC(C)=CC(Br)=C1 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless low melting solid | [Uses]
4-Bromo-2,6-dimethylpyridine is a reagent used in the synthesis of novel isoquinoline derivatives of potential interest for pharmaceutical, biomedical, and energy-related research. |
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Energy Chemical
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Shanghai Ennopharm Co., Ltd.
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