| Identification | Back Directory | [Name]
O-Desmethyl-N-deschlorobenzoyl Indomethacin | [CAS]
50995-53-4 | [Synonyms]
Indomethacin Impurity 6
Indomethacin Impurity 6-d3
5-Hydroxy-2-Methyl-1H-indole-3-acetic Acid
O-Desmethyl-N-deschlorobenzoyl Indomethacin
1H-Indole-3-acetic acid, 5-hydroxy-2-methyl- | [Molecular Formula]
C11H11NO3 | [MDL Number]
MFCD22057167 | [MOL File]
50995-53-4.mol | [Molecular Weight]
205.21 |
| Chemical Properties | Back Directory | [Melting point ]
181-184°C | [storage temp. ]
Hygroscopic, -20°C Freezer, Under Inert Atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Light Brown |
| Hazard Information | Back Directory | [Chemical Properties]
Light Brown Solid | [Uses]
A metabolite of Indomethacin. | [Definition]
ChEBI: Desmethyldeschlorobenzoyl Indomethacin is a member of indole-3-acetic acids. | [References]
[1] KAZUHIKO TORISU . Development of a prostaglandin D2 receptor antagonist: discovery of a new chemical lead[J]. European Journal of Medicinal Chemistry, 2005, 40 5: Pages 505-519. DOI:10.1016/j.ejmech.2004.11.011.
[2] M A EVANS. Indomethacin Metabolism in Isolated Neonatal and Fetal Rabbit Hepatocytes[J]. Pediatric Research, 1981, 15 11: 1406-1410. DOI:10.1203/00006450-198111000-00003.
[3] ANDREW G.M. MORGAN . An evaluation of myeloperoxidase-mediated bio-activation of NSAIDs in promyelocytic leukemia (HL-60) cells for potential cytotoxic selectivity[J]. Toxicology letters, 2017, 280: Pages 48-56. DOI:10.1016/j.toxlet.2017.07.894.
[4] KAZUHIKO TORISU . Discovery of new chemical leads for prostaglandin D2 receptor antagonists[J]. Bioorganic & Medicinal Chemistry Letters, 2004, 14 17: Pages 4557-4562. DOI:10.1016/j.bmcl.2004.06.006. |
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