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51-02-5 Structure

51-02-5 Structure

Identification	Back Directory
[Name] 2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE
[CAS] 51-02-5
[Synonyms] ici38174 PronethalolHCl alderlinhydrochloride nethalidehydrochloride PRONETHALOL HYDROCHLORIDE naphthylisoproterenolhydrochloride 2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol hydrochloride alpha-((isopropylamino)methyl)-naphthalenemethanohydrochloride alpha-((isopropylamino)methyl)-2-naphthalenemethanolhydrochloride alpha-(((1-methylethyl)amino)methyl)-2-naphthalenemethanol,hydrochloride
[Molecular Formula] C15H20ClNO
[MDL Number] MFCD01310435
[MOL File] 51-02-5.mol
[Molecular Weight] 265.78

Chemical Properties	Back Directory
[Melting point ] 184°
[storage temp. ] Store at RT
[form ] Powder
[Water Solubility ] Soluble to 100 mM in water
[IARC] 3 (Vol. 13, Sup 7) 1987
[EPA Substance Registry System] Pronetalol hydrochloride (51-02-5)

Safety Data	Back Directory
[Symbol(GHS) ] GHS05,GHS09
[Signal word ] Danger
[Hazard statements ] H318-H410
[Precautionary statements ] P273-P391-P501-P280-P305+P351+P338-P310
[Toxicity] LD50 in mice (mg/kg): 512 orally, 46 i.v. (Black)

Hazard Information	Back Directory
[Uses] Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs)[1][2].
[Definition] ChEBI: Pronetalol hydrochloride is an organic molecular entity.
[Biological Activity] β -adrenergic antagonist, clinically effective in the treatment of angina pectoris and some arrhythmias.
[in vivo] Pronethalol (0.15 mg/g; daily; for 14 days) stabilizes endothelial differentiation, lumen formation and improves cerebral arteriovenous malformation (AVMs) in Mgp^–/– mice^[2].
[IC 50] β adrenergic receptor
[storage] Store at RT
[References] [1] Aroesty JM, et al. The effects of a beta-adrenergic blocking agent, pronethalol, on digitalis-induced ventricular arrhythmias. Am Heart J. 1966 Apr;71(4):503-8. DOI:10.1016/0002-8703(66)90217-1 [2] Jiayi Yao, et al. Elevated endothelial Sox2 causes lumen disruption and cerebral arteriovenous malformations. J Clin Invest. 2019 Jun 24;129(8):3121-3133. DOI:10.1172/JCI125965 [3] Aroesty JM, et al. The effects of a beta-adrenergic blocking agent, pronethalol, on digitalis-induced ventricular arrhythmias. Am Heart J. 1966 Apr;71(4):503-508.

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