| Identification | Back Directory | [Name]
2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE | [CAS]
51-02-5 | [Synonyms]
ici38174
PronethalolHCl
alderlinhydrochloride
nethalidehydrochloride
PRONETHALOL HYDROCHLORIDE
naphthylisoproterenolhydrochloride
2-ISOPROPYLAMINO-1-(2-NAPHTHYL)ETHANOL HYDROCHLORIDE
1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol hydrochloride
alpha-((isopropylamino)methyl)-naphthalenemethanohydrochloride
alpha-((isopropylamino)methyl)-2-naphthalenemethanolhydrochloride
alpha-(((1-methylethyl)amino)methyl)-2-naphthalenemethanol,hydrochloride | [Molecular Formula]
C15H20ClNO | [MDL Number]
MFCD01310435 | [MOL File]
51-02-5.mol | [Molecular Weight]
265.78 |
| Hazard Information | Back Directory | [Uses]
Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs)[1][2]. | [Definition]
ChEBI: Pronetalol hydrochloride is an organic molecular entity. | [Biological Activity]
β -adrenergic antagonist, clinically effective in the treatment of angina pectoris and some arrhythmias. | [in vivo]
Pronethalol (0.15 mg/g; daily; for 14 days) stabilizes endothelial differentiation, lumen formation and improves cerebral arteriovenous malformation (AVMs) in Mgp–/– mice[2].
| [IC 50]
β adrenergic receptor | [storage]
Store at RT | [References]
[1] Aroesty JM, et al. The effects of a beta-adrenergic blocking agent, pronethalol, on digitalis-induced ventricular arrhythmias. Am Heart J. 1966 Apr;71(4):503-8. DOI:10.1016/0002-8703(66)90217-1
[2] Jiayi Yao, et al. Elevated endothelial Sox2 causes lumen disruption and cerebral arteriovenous malformations. J Clin Invest. 2019 Jun 24;129(8):3121-3133. DOI:10.1172/JCI125965
[3] Aroesty JM, et al. The effects of a beta-adrenergic blocking agent, pronethalol, on digitalis-induced ventricular arrhythmias. Am Heart J. 1966 Apr;71(4):503-508. |
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