| Identification | Back Directory | [Name]
NIALAMIDE | [CAS]
51-12-7 | [Synonyms]
BEIH
Mygal
Espril
Niamid
Niazin
Nyazin
Nyezin
P 1133
Surgex
Novazid
Nuredal
Niamide
NF-XIII
Nialamid
Niamidal
Isalizina
Niaquitil
NIALAMIDE
Psicodisten
Delmoneurina
NIALAMIDE MAO INHIBITOR
Delmoneurinaesprilisalizina
n-benzyl-β-(isonicotinylhydrazino)propionamide
N-(2-(Benzylcarbamyl)ethylamino)isonicotinamide
N-Benzyl-3-(2-isonicotinoylhydrazino)propanamide
N-BENZYL-BETA-(ISONICOTINYLHYDRAZINO)PROPIONAMIDE
N-benzyl-3-(2-isonicotinoylhydrazino)propionamide
N-benzyl-3-(2-isonicotinoylhydrazinyl)propanaMide
N-Benzyl-beta-(isonicotinoylhydrazine)propionamide
N-BENZYL-BETA-[ISONICOTINYL-HYDRAZINE] PROPIONAMIDE
2-(2-(benzylcarbamyl)ethyl)hydrazideisonicotinicacid
1-(2-(benzylcarbamoyl)ethyl)-2-isonicotinoylhydrazine
1-[2-(Benzylcarbamoyl)ethyl]-2-isonicotinoylhydrazine
2-(2-(Benzylcarbamyl)ethyl)hydrazide isonicotinic acid
Isonicitinic acid 2-[(2-benzylcarbamoyl)ethyl]hydrazide
2-(2-(Benzylcarbamoyl)ethyl)hydrazide, isonicotinic acid
ISONICOTINIC ACID 2-[2-(BENZYLCARBAMOYL)-ETHYL]HYDRAZIDE
N-(benzyl)-3-[N'-(pyridine-4-carbonyl)hydrazino]propionamide
N(sup1)-beta-Benzylcarbamoylethyl-N(sup2)isonicotinoylhydrazine
n(sup1)-beta-benzylcarbamoylethyl-n(sup2)-isonicotinoylhydrazine
N-ISONICOTINOYL-N' [BETA-(N-BENZYL-CARBOXAMIDO) ETHYL] HYDRAZINE
N-(phenylmethyl)-3-(2-pyridin-4-ylcarbonylhydrazinyl)propanamide
N-(phenylmethyl)-3-[2-(pyridine-4-carbonyl)hydrazinyl]propanamide
4-pyridinecarboxylicacid2-(3-oxo-3-((phenylmethyl)amino)propyl)hydrazide
4-Pyridinecarboxylic acid, 2-[3-oxo-3-[(phenylmethyl)amino]propyl]hydrazide
N-Benzyl-β-(isonicotinylhydrazino)propionamide, Pyridine-4-carboxylic 2-[2-(benzylcarbamoyl)ethyl]hydrazide, N-Isonicotinoyl-Nμ-[β-(N-benzylcarboxamido)ethyl]hydrazine | [EINECS(EC#)]
200-079-3 | [Molecular Formula]
C16H18N4O2 | [MDL Number]
MFCD00010106 | [MOL File]
51-12-7.mol | [Molecular Weight]
298.34 |
| Chemical Properties | Back Directory | [Appearance]
White, crystalline powder. Low solubility in water; good solubility in slightly acid solution. It is stable in crystalline form, suspension, and
solution. | [Melting point ]
152-154 °C(lit.)
| [Boiling point ]
439.76°C (rough estimate) | [density ]
1.1183 (rough estimate) | [refractive index ]
1.6000 (estimate) | [storage temp. ]
−20°C
| [solubility ]
ethanol: clear to hazy
| [pka]
11.13±0.23(Predicted) | [Merck ]
13,6515 | [BRN ]
492941 |
| Hazard Information | Back Directory | [Uses]
MAO inhibitor | [Hazard]
Toxic in overdose. | [Chemical Properties]
White, crystalline powder. Low solubility in water; good solubility in slightly acid solution. It is stable in crystalline form, suspension, and
solution. | [Originator]
Niamid,Pfizer,US,1959 | [Definition]
ChEBI: 3-[[oxo(pyridin-4-yl)methyl]hydrazo]-N-(phenylmethyl)propanamide is an organooxygen compound and an organonitrogen compound. It is functionally related to a beta-amino acid. | [Manufacturing Process]
Methyl acrylate, 28.0 g (0.4 mol) was added dropwise during one hour to a
solution containing 54.8 g (0.4 mol) of isonicotinic acid hydrazide (isoniazid)
and 10 ml of glacial acetic acid in 400 ml of tertiary butyl alcohol. The
resulting solution then was heated for 18 hours on a steam bath.
Concentration of the reaction mixture to 100 ml yielded 13.0 g of unreacted
isonicotinic acid hydrazide. The filtrate was concentrated to a thick syrup
which was triturated with anhydrous ether and recrystallized from isopropyl
alcohol; MP 87°C to 88.5°C. Elemental analysis of the product gave 1-
isonicotinyl-2-(β-carbomethoxyethyl)hydrazine.
A slurry of 7.5 g (0.034 mol) of 1-isonicotinyl-2-(carbomethoxyethyl)-
hydrazine and 5 ml of benzylamine is heated with stirring at 130°C for three
hours. The cooled mass is then recrystallized from ethyl acetate to yield white
needles melting at 151.1°C to 152.1°C. | [Brand name]
Nialamid;Niamidal;Niamide;Niaquital;Niaquitil;Novazid;Nuredal;Psyco-retard;Surgexl. | [Therapeutic Function]
Antidepressant | [World Health Organization (WHO)]
Nialamide, a monoamine oxidase inhibitor (MAOI), was
introduced in 1959 for the treatment of depressive illness. Subsequently concern
regarding potentially serious interactions between MAOIs and foods containing
tyramine inspired much restrictive regulatory action. However, MAOIs still retain a
place in the treatment of serious depressive illness although there is no
international consensus on which compounds should be preferred. Thus nialamide
remains available in several countries. | [General Description]
Nialamide is an antidepressant drug and its effect on β-adrenergic receptor-adenylate cyclase system of rat pineal gland has been studied. Antidepressant action of the combination of nialamide and 5-hydroxytryptophan has been evaluated. | [Safety Profile]
Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion.Mutation data reported. Experimental reproductiveeffects. An antidepressant. When heated to decompositionit emits toxic fumes of NOx. | [storage]
Store at -20°C |
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Musechem
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www.musechem.com |
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