| Identification | Back Directory | [Name]
aphidicolin-17-monoacetate | [CAS]
51103-57-2 | [Synonyms]
Aphidicolin 17-acetate
aphidicolin-17-monoacetate
8,11a-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol, tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, 9-acetate, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)- | [Molecular Formula]
C22H36O5 | [MOL File]
51103-57-2.mol | [Molecular Weight]
380.52 |
| Hazard Information | Back Directory | [Uses]
Aphidicolin 17-acetate is a selective eukaryotic DNA polymerase α inhibitor. Aphidicolin 17-acetate does not inhibit DNA polymerase β and γ. Aphidicolin 17-acetate markedly inhibits the in vivo DNA synthesis of sea urchin embryos and HeLa cells but not RNA and protein syntheses[1]. | [References]
[1] Haraguchi T, et al. Specific inhibitors of eukaryotic DNA synthesis and DNA polymerase alpha, 3-deoxyaphidicolin and aphidicolin-17-monoacetate. Nucleic Acids Res. 1983 Feb 25;11(4):1197-209. DOI:10.1093/nar/11.4.1197 |
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