| Identification | Back Directory | [Name]
5-Nitro-1-tetralone | [CAS]
51114-73-9 | [Synonyms]
5-Nitro-1-tetralone
5-Nitro-α-tetralone
5-NITRO-A-TETRALONE
5-Nitro-3,4-dihydronaphthalen-1(2H)
5-Nitro-3,4-dihydro-2H-naphthalen-1-one
3,4-dihydro-5-nitronaphthalen-1(2H)-one
5-nitro-3,4-dihydronaphthalen-1(2H)-one
5-nitro-1,2,3,4-tetrahydronaphthalen-1-one | [Molecular Formula]
C10H9NO3 | [MDL Number]
MFCD09751533 | [MOL File]
51114-73-9.mol | [Molecular Weight]
191.183 |
| Chemical Properties | Back Directory | [Melting point ]
103-104 °C | [Boiling point ]
349.9±31.0 °C(Predicted) | [density ]
1.322±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [Appearance]
White to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis Reference(s)]
Journal of Medicinal Chemistry, 19, p. 472, 1976 DOI: 10.1021/jm00226a004 | [Synthesis]
The general procedure for the synthesis of 5-nitro-α-tetralone from 4-(2-nitrophenyl)butyric acid was as follows: first, 1 g of 4-(2-nitrophenyl)butyric acid (NPBS, 4.78 mmol) and 18 g of trifluoromethanesulfonic acid (TFMS) were added to a 100 mL two-necked flask fitted with a reflux condenser and magnetic stirrer at 20 °C. Under stirring, the reaction mixture was placed in an oil bath preheated to 130 °C and stirred continuously at this temperature for 45 min. Upon completion of the reaction, the mixture was cooled and transferred to a microdistillation unit. Most of the excess TFMS was removed by distillation at 52 °C and 0.5 mbar.After distillation, the bottom residue contained 0.914 g of 5-nitro-3,4-dihydro-1(2H)-naphthalenone and 3.44 g of TFMS (as determined by the GC-ISTD/internal standard method) in 99.3% yield, with 100% conversion to NPBS and 99.3% selectivity. | [References]
[1] Patent: EP1369412, 2003, A1. Location in patent: Page 6
[2] Patent: EP1369412, 2003, A1. Location in patent: Page 6
[3] Patent: US2003/176722, 2003, A1 |
|
| Company Name: |
Tetranov Biopharm
|
| Tel: |
13526569071 |
| Website: |
www.leadmedpharm.com/index.html |
|