| Identification | Back Directory | [Name]
Anisacril | [CAS]
5129-14-6 | [Synonyms]
Anisacril
α-(o-Anisyl)-β,β-diphenylacrylsaeure
2-(2-methoxyphenyl)-3,3-di(phenyl)acrylic acid
2-(2-methoxyphenyl)-3,3-di(phenyl)prop-2-enoic acid
Benzeneacetic acid, α-(diphenylmethylene)-2-methoxy-
2-(2-methoxyphenyl)-3,3-diphenylacrylic acid(WXG02282) | [Molecular Formula]
C22H18O3 | [MOL File]
5129-14-6.mol | [Molecular Weight]
330.38 |
| Hazard Information | Back Directory | [Originator]
SCF 16046,Smith Kline | [Manufacturing Process]
A solution of Grignard reactive (prepared from 247 g of o-bromoanisole and
31.6 g of magnesium in 1500 ml of ether) is added dropwise to a solution of
91 g of diphenyl pyruvic acid in ether. The mixture is refluxed for 2 hours.
After cooling to the reaction mixture is added 5% hydrochloric acid and the
product is extracted with 5% solution of sodium hydroxide. α-(o-Anisyl)-β,β-
diphenyl lactic acid is precipitated by addition of concentrated hydrochloric
acid; yield 62 g, melting point 194-195°C.
4 g of α-(o-anisyl)-β,β-diphenyl lactic acid is heated at 210-215°C for 10-15
min. The α-(o-anisyl)-β,β-diphenyl acrylic acid is recrystallized from benzene,
yield 2.85 g (74%), melting point 195-196°C. | [Therapeutic Function]
Anorexic, Antihyperlipidemic |
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