| Identification | Back Directory | [Name]
N-pyridin-2-yl[1,1'-biphenyl]-4-acetamide | [CAS]
51484-40-3 | [Synonyms]
difenpiramide
Difenpyramide
N-(2-Pyridinyl)-1,1'-biphenyl-4-acetamide
N-pyridin-2-yl[1,1'-biphenyl]-4-acetamide
2-(4-phenylphenyl)-N-pyridin-2-ylacetamide
[1,1'-Biphenyl]-4-acetamide, N-2-pyridinyl-
2-([1,1'-Biphenyl]-4-yl)-N-(pyridin-2-yl)acetamide | [EINECS(EC#)]
257-235-9 | [Molecular Formula]
C19H16N2O | [MDL Number]
MFCD00869423 | [MOL File]
51484-40-3.mol | [Molecular Weight]
288.34 |
| Hazard Information | Back Directory | [Originator]
Difenax,Zambeletti,Italy,1977 | [Definition]
ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group from biphenyl-4-ylacetic acid with the amino group of 2-aminopyridine. Used for treatment of rheumatoid arthritis. | [Manufacturing Process]
23 g (0.1 mol) diphenylacetic acid chloride dissolved in 300 cc anhydrous
ethyl ether are slowly added dropwise to a solution of 19 g (0.2 mol) 2-
aminopyridine in 300 cc anhydrous ethyl ether. The reaction mixture is
agitated and the temperature is kept at between 5°C and 10°C with an ice
bath. After the addition has been completed, the agitation of the mixture is
continued and the temperature is allowed to rise to 20°C to 25°C.
After leaving to stand for a few hours, the gummy precipitate solidifies and
becomes filterable. After separating off the precipitate, the ether is evaporated
under reduced pressure to a volume of about 100 cc.
The ether is left to stand at a low temperature below 10°C when the
remaining portion of the product precipitates and is filtered off and added to
the first precipitate. The product thus obtained is thoroughly washed, first in
water and then in a solution of sodium bicarbonate, and then again in water.
After drying in air, the product is crystallized from anhydrous ethanol or from
acetone and water. The analytical data correspond to calculated values. Yield
is 18 g; MP 122°C to 124°C. | [Therapeutic Function]
Antiinflammatory |
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