| Identification | Back Directory | [Name]
2-Propen-1-one, 1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(4-methoxyphenyl)-, (2E)- | [CAS]
51589-67-4 | [Synonyms]
4-methoxylonchocarpin
2-Propen-1-one, 1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(4-methoxyphenyl)-, (2E)- | [Molecular Formula]
C21H20O4 | [MOL File]
51589-67-4.mol | [Molecular Weight]
336.39 |
| Chemical Properties | Back Directory | [Boiling point ]
535.2±50.0 °C(Predicted) | [density ]
1.193±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
7.22±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
4-Methoxylonchocarpin is an orally active anti-inflammatory agent. 4-methoxylonchocarpin inhibits the binding of LPS to Toll-like Receptor (TLR) TLR4 to inhibit NF-κB activation and TNF Receptor and IL-6 expression. 4-Methoxylonchocarpin also inhibits the phosphorylation of TGF-beta activated kinase 1 and TNBS-induced expression of IL-1β, IL-17A, and TNF. 4-methoxylonchocarpin can improve 2,4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mouse model[1]. | [Definition]
ChEBI: 4-Methoxylonchocarpin is a member of chalcones. | [References]
[1] Jang HM, et al. 4-Methoxylonchocarpin attenuates inflammation by inhibiting lipopolysaccharide binding to Toll-like receptor of macrophages and M1 macrophage polarization. Int Immunopharmacol. 2017 Apr;45:90-97. DOI:10.1016/j.intimp.2017.02.003 |
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