| Identification | Back Directory | [Name]
Taurochenodeoxycholic acid | [CAS]
516-35-8 | [Synonyms]
TCDCA
C05465
Chenyltaurine
12-Deoxycholyltaurine
Taurochenodeoxycholic
12-Desoxycholyltaurine
Chenodeoxycholyltaurine
aurochenodeoxycholicaci
Chenodeoxycholoyltaurine
2-[4-(3,7-dihydroxy-10,13-
Taurochenodeoxycholic acid
Chenodeoxytaurocholic acid
Taurocholic chenodeoxycholic acid
Taurochenodeoxycholic acid, 99.5%
N-(3α,7α-dihydroxy-5β-cholan-24-oyl)taurine
3α,7α-Dihydroxy-N-(2-sulfoethyl)-5β-cholan-24-aMide
N-(2-Sulfoethyl)-3α,7α-dihydroxy-5β-cholane-24-amide
Taurochenodeoxycholic Acid-d5 (Major)
DISCONTINUED. Please see T008133
2-{[(3alpha,5beta,7alpha,20xi)-3,7-dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonic acid
2-(4-(3,7-dihydroxy-10,13-diMethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanaMido)ethanesulfonic acid
2-((R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethanesulfonic acid
2-[4-(3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoylamino]ethanesulfonic acid
2-[[(4R)-4-[(3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid | [Molecular Formula]
C26H45NO6S | [MDL Number]
MFCD00232922 | [MOL File]
516-35-8.mol | [Molecular Weight]
499.7 |
| Chemical Properties | Back Directory | [Melting point ]
186-200°C | [density ]
1.216±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform, Methanol | [form ]
Solid | [pka]
1.42±0.50(Predicted) | [color ]
White to Pale Beige | [InChIKey]
BHTRKEVKTKCXOH-ZNKJZDQHNA-N | [SMILES]
[C@@]12([H])CC[C@H]([C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@@]1(C)CC[C@]1([H])[C@@]3(C)CC[C@@H](O)C[C@@]3([H])C[C@@H](O)[C@@]21[H] |&1:0,4,5,18,22,24,28,31,34,36,r| |
| Hazard Information | Back Directory | [Chemical Properties]
White crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from animal bile. | [Uses]
Taurochenodeoxycholic Acid is a bile acid conjugate and metabolite Taurolithocholic Acid (T009100) with antiinflammatory activity. Taurochenodeoxycholic Acid has been shown to inhibit hepatocyte apoptosis through suppression of Bid translocation to mitochondria. | [Definition]
ChEBI: A bile acid taurine conjugate of chenodeoxycholic acid. | [in vivo]
Taurochenodeoxycholic acid (12-Deoxycholyltaurine; 0.05, 0.1g/kg) decreases the pulmonary coefficient in the model mice and reduces the pathological damages on their lungs; it can decrease the expression levels of TNF-α and TIMP-2 in pulmonary tissues in the pulmonary fibrosis mice and has no significant effects on MMP2[2].
?
Taurochenodeoxycholic acid significantly normalizes the clinical inflammatory parameters, prevented indomethacin-induced increases in the biliary contents of secondary bile acids and hydrophobicity index, and tended to attenuate the intestinal inflammation[3].
?
Taurochenodeoxycholic acid significantly suppresses paw swelling and polyarthritis index, increases the loss body weight and index of thymus and spleen, and amends radiologic changes in AA rats. The overproduction and mRNA expression of TNF-α, IL-1β and IL-6 are remarkably suppressed in serum and synovium tissue of all TCDCA-treated rats[4].
| [IC 50]
Microbial Metabolite; Human Endogenous Metabolite |
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