| Identification | Back Directory | [Name]
KI23057 | [CAS]
516523-31-2 | [Synonyms]
KI23057
2-[2-[4-[4-(4-tert-butylanilino)phenoxy]-6-methoxyquinolin-7-yl]oxyethylamino]ethanol
Ethanol, 2-[[2-[[4-[4-[[4-(1,1-dimethylethyl)phenyl]amino]phenoxy]-6-methoxy-7-quinolinyl]oxy]ethyl]amino]- | [Molecular Formula]
C30H35N3O4 | [MDL Number]
MFCD18643369 | [MOL File]
516523-31-2.mol | [Molecular Weight]
501.62 |
| Hazard Information | Back Directory | [Uses]
Ki 23057 is a competitive, orally active inhibitor for tyrosine kinase, which inhibits the phosphorylation of K-samII/FGF-R2, VEGF-R1, VEGF-R2, PDGF-Rβ and c-Kit, with IC50s of 88, 69, 83, 100 and 480 nM. Ki 23057 inhibits the proliferation of sclerogastric cancer cells OCUM-2MD3 and OCUM-8, and induces apoptosis. Ki 23057 exhibits antitumor efficacy in mouse models[1]. | [References]
[1] Nakamura K, et al., A novel molecular targeting compound as K-samII/FGF-R2 phosphorylation inhibitor, Ki23057, for Scirrhous gastric cancer. Gastroenterology. 2006 Nov;131(5):1530-41. DOI:10.1053/j.gastro.2006.08.030 |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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