| Identification | Back Directory | [Name]
CYCLEANINE | [CAS]
518-94-5 | [Synonyms]
Cycleanin
CYCLEANINE
CYCLEANINE USP/EP/BP
o-Methylnorcycleanine
Methylisochondodendrine
Cycleanine (6ci,7ci,8ci)
Dimethylisochondodendrine
o,o-Dimethylisochondodendrin
o,o-Dimethylisochondrodendrine
7,7'-O,O-DiMethylisochondodendrine
(1R)-2,2'-Dimethyl-6,6',7,7'-tetramethoxy-7,18:11',18-diseco-8,18:12',18-dicyclotubocuraran
8,11:20,23-Dietheno-1H,12H-[1,10]dioxacyclooctadecino[2,3,4-ij:11,12,13-i'j']diisoquinoline, 2,3,12a,13,14,15,24,24a-octahydro-5,6,17,18-tetramethoxy-1,13-dimethyl-, (12aR,24aR)-
8,11:20,23-DIETHENO-1H,12H-[1,10]DIOXACYCLOOCTADECINO[2,3,4-IJ:11,12,13-I'J']DIISOQUINOLINE,2,3,12A,13,14,15,24,24A-OCTAHYDRO-5,6,17,18-TETRAMETHOXY-1,13-DIMETHYL-, [12AR-(12AR*,24AR*)]-
8,11:20,23-Dietheno-1H,12H-(1,10)dioxacyclooctadecino(2,3,4-ij:11,12,13-I'J')diisoquinoline, 2,3,12A,13,14,15,24,24A-octahydro-1,13-dimethyl-5,6,17,18-tetramethoxy-, (12ar-(12ar*,24ar*))-
CYCLEANINE: 8,11:20,23-DIETHENO-1H,12H-[1,10]DIOXACYCLOOCTADECINO[2,3,4-IJ:11,12,13-I'J']DIISOQUINOLINE,2,3,12A,13,14,15,24,24A-OCTAHYDRO-5,6,17,18-TETRAMETHOXY-1,13-DIMETHYL-, [12AR- (12AR*,24AR*)]-, | [Molecular Formula]
C38H42N2O6 | [MDL Number]
MFCD00238567 | [MOL File]
518-94-5.mol | [Molecular Weight]
622.75 |
| Chemical Properties | Back Directory | [Melting point ]
272-273 °C | [Boiling point ]
691.6±55.0 °C(Predicted) | [density ]
1.172±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture and light | [solubility ]
Acetone: soluble; Dichloromethane: soluble; DMSO: soluble; Ethyl Acetate: soluble | [form ]
A solid | [pka]
7.56±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from Bletilla striata, Dibulacanthus radiata, Dibulacanthus glabra, Amur ringworm, Dibulacanthus sichuanensis, Angelica dahurica, and Tenghuo xisheng. | [Uses]
Cycleanine is an alkaloid obtained from the Triclisia subcordata Oliv (Menispermeaceae) which is a medicinal plant used to treat various diseases in West Africa. Displays in-vitro anti-ovarian cancer activity. | [Definition]
ChEBI: Cycleanine is a member of isoquinolines and a bisbenzylisoquinoline alkaloid. | [Synthesis]
The crude powder of Verticillium root was taken 10.5 kg, extracted with 95% ethanol (8 times quantity×3), the ethanol solution was concentrated to obtain the crude extract, which was added to 1.0 L water, adjusted pH3 with 2 mol-L-1 hydrochloric acid, the | [in vivo]
Cycleanine inhibits the KCl-induced contraction of rabbit aortic rings with an IC50 of 0.8 nM[1].
| [IC 50]
L-type calcium channel |
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