Identification | Back Directory | [Name]
Acetic acid, 2-[[4-[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]- | [CAS]
518303-27-0 | [Synonyms]
Acetic acid, 2-[[4-[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]- | [Molecular Formula]
C22H23NO5S2 | [MOL File]
518303-27-0.mol | [Molecular Weight]
445.55 |
Hazard Information | Back Directory | [Uses]
Mcl1-IN-15 (Compound 7) is the inhibitor for myeloid cell leukemia 1 (Mcl-1) with an IC50 of 8.73 μM. Mcl1-IN-15 inhibits Mcl1-BH3 peptide interaction, activates the Bak/Bax-mediated apoptosis and exhibits antitumor activity[1]. | [IC 50]
Mcl-1: 8.73 μM (IC50) | [References]
[1] Abulwerdi FA, et al., 3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. J Med Chem. 2014 May 22;57(10):4111-33. DOI:10.1021/jm500010b |
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