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518303-27-0

518303-27-0 Structure

518303-27-0 Structure
IdentificationBack Directory
[Name]

Acetic acid, 2-[[4-[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-
[CAS]

518303-27-0
[Synonyms]

Acetic acid, 2-[[4-[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-
[Molecular Formula]

C22H23NO5S2
[MOL File]

518303-27-0.mol
[Molecular Weight]

445.55
Chemical PropertiesBack Directory
[Boiling point ]

637.9±65.0 °C(Predicted)
[density ]

1.42±0.1 g/cm3(Predicted)
[storage temp. ]

2-8°C
[pka]

2.41±0.30(Predicted)
Hazard InformationBack Directory
[Uses]

Mcl1-IN-15 (Compound 7) is the inhibitor for myeloid cell leukemia 1 (Mcl-1) with an IC50 of 8.73 μM. Mcl1-IN-15 inhibits Mcl1-BH3 peptide interaction, activates the Bak/Bax-mediated apoptosis and exhibits antitumor activity[1].
[IC 50]

Mcl-1: 8.73 μM (IC50)
[References]

[1] Abulwerdi FA, et al., 3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. J Med Chem. 2014 May 22;57(10):4111-33. DOI:10.1021/jm500010b
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