| Identification | Back Directory | [Name]
ASP-ARG-VAL-TYR-ILE-HIS-PRO | [CAS]
51833-78-4 | [Synonyms]
A779
DRVYIHP
Ang-(1-7)
Merotocin
DRVYIH{D-Ala}
H2N-DRVYIHP-OH
angiotension 1-7
angiotensinii(1-7
ANGIOTENSIN (1-7)
ANGIOTENSIN 1/2 (1-7)
Angiotensin 1-7, >98%
ANGIOTENSIN I/II (1-7)
ANGIOTENSIN CANINE RAT
Angiotensin I(1-7)【rat】
Angiotensin II(1-7)【rat】
(DES-PHE8) ANGIOTENSIN II
Angiotensin (1-7) xTFA salt
ANGIOTENSIN II FRAGMENT 1-7
ASP-ARG-VAL-TYR-ILE-HIS-PRO
L-ASP-ARG-VAL-TYR-ILE-HIS-PRO
ANGIOTENSIN I/II (1-7), HUMAN
H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-OH
Angiotensin ii (1-7) heptapeptide
Angiotensin 1-7
(Angiotensin (1-7)
1-7-Angiotensin II, 5-L-isoleucine-
angiotensin fragment 1-7 human acetate
ANGIOTENSIN (HUMAN, 1-7) (CANINE, RAT)
angiotensin fragment 1-7 acetate hydrate
Angiotensin Fragment1-7 acetate salt hydrate
Angiotensin Fragment1-7 hydrate acetate salt
Angiotensin I/II (1-7)|A779|Angiotensin,Canine,Rat
Angiotensin ii, 5-L-isoleucine-8-de-L-phenylalanine-
Aspartyl-argininyl-valinyl-tyrosinyl-isoleucinyl-histidinyl-proline
Angiotensin I/II (1-7) trifluoroacetate salt H-Asp-Arg-Val-Tyr-Ile-His-Pro-OH trifluoroacetate salt
Angiotensin I/II (1-7) Asp-Arg-Val-Tyr-Ile-His-Pro | [Molecular Formula]
C41H62N12O11 | [MDL Number]
MFCD00153513 | [MOL File]
51833-78-4.mol | [Molecular Weight]
899 |
| Chemical Properties | Back Directory | [Melting point ]
>202°C (dec.) | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated) | [form ]
powder
| [pka]
3.29±0.20(Predicted) | [color ]
White to Off-White | [Water Solubility ]
Soluble to 1 mg/ml in water | [InChIKey]
PVHLMTREZMEJCG-UHFFFAOYSA-N | [SMILES]
CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(N)CC(O)=O)C(C)C)C(=O)NC(Cc2cnc[nH]2)C(=O)N3CCCC3C(O)=O |
| Hazard Information | Back Directory | [Uses]
Angiotensin (1-7) can be used in biological study and engineering or chemical process of mechanisms of peptide oxidation by hydroxyl radicals. | [Definition]
ChEBI: Ile(5)-angiotensin II (1-7) is an angiotensin compound consisting of the linear heptapeptide sequence L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro. It has a role as a vasodilator agent. It is a tautomer of an Ile(5)-angiotensin II (1-7) dizwitterion. | [Biological Activity]
ang-(1-7) (h - asp - arg - val - tyr - ile - his - pro - oh) is an endogenous peptide fragment that can be produced from ang i or ang ii via endo- or carboxy-peptidases respectively[1].as described for ang ii, ang-(1-7) also has a broad range of effects in different organs and tissues and goes beyond its initially described cardiovascular and renal actions. those effects are mediated by mas and can counter-regulate most of the deleterious effects of ang ii. the interaction ang-(1-7)/mas regulates different signaling pathways, such as pi3k (phosphoinositide 3-kinase)/akt and erk (extracellular signal-regulated kinase) pathways and involves downstream effectors such as no, foxo1 (forkhead box o1) and cox-2 (cyclo-oxygenase-2). through these mechanisms, ang-(1-7) is able to improve pathological conditions including fibrosis and inflammation in organs such as lungs, liver and kidney. [2]in addition, this heptapeptide has positive effects on metabolism, increasing the glucose uptake and lipolysis while decreasing insulin resistance and dyslipidemia. ang-(1-7) is also able to improve cerebroprotection against ischemic stroke, besides its effects on learning and memory. the reproductive system can also be affected by ang-(1-7) treatment, with enhanced ovulation, spermatogenesis and sexual steroids synthesis. finally, ang-(1-7) is considered a potential anti-cancer treatment since it is able to inhibit cell proliferation and angiogenesis.[2]fig. 1: formula of angiotensin (1-7)fig. 2: cascade of the processing of angiotensin peptides and their interaction with at1 and at1-7 receptor systems. | [Biochem/physiol Actions]
Angiotensin I metabolite that is an AT2 receptor agonist. | [storage]
Store at -20°C | [References]
1. Santos et al (2000) Angiotensin-(1-7): an update. Regul.Pept. 91 45.2. Danielle G. P., Thiago V., Robson A. S. Angiotensin-(1-7): beyond the cardio-renal actions. Clinical Science (2013) 124, (443–456) |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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