| Identification | Back Directory | [Name]
Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- | [CAS]
5184-64-5 | [Synonyms]
ESI-05
NSC 116966
ESI-05
(ESI05)
ESI-05 >=98% (HPLC)
MESITYL P-TOLYL SULFONE
1,3,5-trimethyl-2-tosylbenzene
1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene
Benzene,1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]- | [Molecular Formula]
C16H18O2S | [MDL Number]
MFCD00091573 | [MOL File]
5184-64-5.mol | [Molecular Weight]
274.38 |
| Chemical Properties | Back Directory | [Melting point ]
119-120 °C | [Boiling point ]
426.7±45.0 °C(Predicted) | [density ]
1.129±0.06 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: soluble | [form ]
powder | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
ESI-05 has been used to study the effect of protein exchange directly activated by cAMP 2 on traumatic brain injury. | [Biochem/physiol Actions]
ESI-05 is a selective inhibitor against cAMP-regulated guanine nucleotide exhange factor (GEF) EPAC2 (Exchange factor directly activated by cAMP 2) activation by targeting an EPAC2-specific allosteric site at the interface of the two cAMP-binding domains. ESI-05 inhibits EAPC2, but not EPAC1 or PKA, activation by cAMP in a highly potent (IC50 = 430 nM; 25 μM cAMP) and cAMP-competitive manner in cell-free assays, and suppresses cAMP analog 007-AM-induced cellular Rap1 activation in EPAC2-, but not EPAC1-, expressing HEK293 transfectants. | [in vivo]
ESI-05 (2, 4, and 8 mg/kg) decreases neuronal apoptosis by inhibiting the p38/BIM pathway in vivo[2]. | Animal Model: | Intracranial hemorrhage (ICH) model[2] | | Dosage: | 2, 4, and 8 mg/kg | | Administration: | | | Result: | Decreased the apoptosis rate of nerve cells in the cortex accompanied by a corresponding decrease in the protein expression of phosphorylated p38, Bcl-2like protein 11 (BIM), and caspase-3. |
| [storage]
Store at RT |
|
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