| Identification | Back Directory | [Name]
8-deazafolic acid | [CAS]
51989-25-4 | [Synonyms]
NSC173522
NSC-173522
NSC 173522
8-deazafolic acid
8Deazafolic acid,8 Deazafolic acid
N-{4-[(2-amino-4-oxo-3,4-dihydro-pyrido[3,2-d]pyrimidin-6-ylmethyl)-amino]-benzoyl}-glutamic acid
L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxopyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]- | [Molecular Formula]
C20H20N6O6 | [MOL File]
51989-25-4.mol | [Molecular Weight]
440.41 |
| Hazard Information | Back Directory | [Uses]
8-Deazafolic acid is an antimicrobial drug for the folate-dependent bacteria, Streptococcus faecium (ATCC 8043) and Lactobacillus casei (ATCC 74691). 8-Deazafolic acid has activity against lymphoid leukemia L1210 in mice[1]. | [References]
[1] Carroll Temple Jr, et al. New synthesis of N-[4-[[(2-amino-4(3H)-oxopyrido[3,2-d]pyrimidin-6-yl)methyl]amino]benzoyl]-L-glutamic acid (8-deazafolic acid) and the preparation of some 5,6,7,8-tetrahydro derivatives. J. Med. Chem. 1981, 24, 10, 1254–1258. |
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