| Identification | Back Directory | [Name]
Everninate methyl | [CAS]
520-43-4 | [Synonyms]
Sparassol
Everninate methyl
methyl everninate
4-Methoxy-2,6-cresotic acid methyl
Orsellinic acid methyl ester 4-methyl ether
methyl 2-hydroxy-4-methoxy-6-methylbenzoate
2-Hydroxy-4-methoxy-6-methylbenzoic acid methyl ester
2-Methyl-4-methoxy-6-hydroxybenzoic acid methyl ester
Benzoic acid, 2-hydroxy-4-methoxy-6-methyl-, methyl ester
enzoic acid, 2-hydroxy-4-methoxy
-6-methyl-, methyl ester | [Molecular Formula]
C10H12O4 | [MDL Number]
MFCD00597207 | [MOL File]
520-43-4.mol | [Molecular Weight]
196.2 |
| Chemical Properties | Back Directory | [Melting point ]
67-68°; mp 170° | [Boiling point ]
302.6±37.0 °C(Predicted) | [density ]
1.181±0.06 g/cm3(Predicted) | [solubility ]
Slightly soluble in cold water and cold alcohol, soluble in hot water and hot alcohol, freely soluble in oils. | [pka]
9.49±0.15(Predicted) | [Odor]
Sweet, somewhat earthy-musty odor of excellent tenacity. |
| Hazard Information | Back Directory | [Uses]
Methyl everninate is the major constituent of the deuterochloroform. Methyl everninate, rhodomollosides A and B are the derivatives of Methyl everninate, with cytotoxicity against RAW264.7 cells. Both of they shows inhibitory effects with a lipopolysaccharide (LPS)-stimulated murine macrophages RAW 264.7 cells model[1][2]. | [Definition]
ChEBI: 2-hydroxy-4-methoxy-6-methylbenzoic acid methyl ester is a methoxybenzoic acid. | [Production Methods]
Everninate methyl can be produced:
1) by Methylesterification of Eveminic acid.
This esterification takes place to a measurable degree when Oakmoss is extracted
with Methyl alcohol.
Eveminic acid is also a product of alkaline
hydrolysis of Evemic acid which occurs
naturally in Oakmoss. Evemic acid can be
synthesized via Evemic aldehyde. This
aldehyde is considered as an important
odor factor of Oakmoss.
2) from Methylorsellinate plus Diazomethane. | [References]
[1] Yang XR, et al. Rhodomollosides A and B, glycosides of methyl everninate from the aerial parts of Rhododendron molle. J Asian Nat Prod Res. 2022 Nov;24(11):1025-1032. DOI:10.1080/10286020.2021.2011241
[2] Hackl T, et al. Three ent-eudesmenones from the liverwort Plagiochila bifaria. Phytochemistry. 2006 Apr;67(8):778-83. DOI:10.1016/j.phytochem.2006.01.001 |
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Shureli Biopharma Co.,Ltd
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