| Identification | Back Directory | [Name]
calendic acid | [CAS]
5204-87-5 | [Synonyms]
calendic acid
8t,10t,12c-CLN
(8E,10E,12Z)-8,10,12-Octadecatrienoic acid
(8E,10E,12Z)-Octadeca-8,10,12-trienoic acid
8,10,12-Octadecatrienoic acid, (8E,10E,12Z)- | [Molecular Formula]
C18H30O2 | [MOL File]
5204-87-5.mol | [Molecular Weight]
278.43 |
| Hazard Information | Back Directory | [Uses]
Calendic acid (8(E),10(E),12(Z)-Octadecatrienoic acid) is a conjugated polyunsaturated fatty acid (PUFA) that can be isolated from C. officinalis seed oil. Calendic acid has anticancer activity[1][2][3]. | [Definition]
ChEBI: A conjugated linolenic acid having three double bonds located at positions 8, 10 and 12 (the 8E,10E,12Z-geoisomer) | [References]
[1] Crombie L, et al. The biosynthesis of calendic acid, octadeca-(8 E, 10 E, 12 Z)-trienoic, acid, by developing marigold seeds: origins of (E, E, Z) and (Z, E, Z) conjugated triene acids in higher plants. Journal of the Chemical Society, Perkin Transactions 1, 1985: 2425-2434.
[2] Yasui Y, et al. Growth inhibition and apoptosis induction by all-trans-conjugated linolenic acids on human colon cancer cells. Anticancer Res. 2006 May-Jun;26(3A):1855-60. PMID:16827117
[3] Shinohara N, et al. jacaric acid, a linolenic acid isomer with a conjugated triene system, reduces stearoyl-CoA desaturase expression in liver of mice. J Oleo Sci. 2012;61(8):433-41. DOI:10.5650/jos.61.433 |
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