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52435-06-0

52435-06-0 Structure

52435-06-0 Structure
IdentificationBack Directory
[Name]

[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate
[CAS]

52435-06-0
[Synonyms]

AY25
AY-25
LRH-A
AY 25
LHRH-A
LHRH-A2
TAP 127
AY-25205
Wy-18481
leuprolideIS
[D-Ala6]des-Gly10-GnRH ethylamide
(Des-Gly10,D-Ala6,proethylamide9)-LRH
[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate
luteinizing hormone releasing hormone (D-Ala^<6^>) analog
[D-Ala6]des-Gly10-gonadotropin releasing hormone ethylamide
[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate USP/EP/BP
5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-D-Ala-L-Leu-L-Arg-L-Pro-NHEt
1-9-Luteinizing hormone-releasing factor (swine), 6-D-alanine-9-(N-ethyl-L-prolinamide)-
(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
[Molecular Formula]

C56H78N16O12
[MOL File]

52435-06-0.mol
[Molecular Weight]

1167.32
Chemical PropertiesBack Directory
[density ]

1.48±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

9.82±0.15(Predicted)
[color ]

White to off-white
[Sequence]

{Pyr}-His-Trp-Ser-Tyr-{d-Ala}-Leu-Arg-Pro-NHEt
Safety DataBack Directory
[Symbol(GHS) ]


GHS08
[Signal word ]

Danger
[Hazard statements ]

H360
Hazard InformationBack Directory
[Chemical Properties]

Off-white freeze-dried powder. Soluble in water and saline.
[Uses]

(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (Surfagon, Mwt 1167.34 Da) is an agonist of gonadotropin-releasing hormone (GnRH). (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH can be used as an internal standard for the LC-MS analysis of leuprorelide acetate. (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH has potential applications in biochemical analysis and fertility[1][2][3].
[in vivo]

(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (2 μg/kg; i.p.; single dose) significantly increases anxiety behavior in adult male rats with and without gonadectomy[2].
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (50 μg; single dose) improves the fertility of cows after fertilization and prevents embryo death when combined with Ainil (30 μL/kg)[3].

[References]

[1] Wan B, et al. Polymer source affects in vitro-in vivo correlation of leuprolide acetate PLGA microspheres. Int J Pharm. 2022 Sep 25;625:122032. DOI:10.1016/j.ijpharm.2022.122032
[2] Masalova OO, et al. Effect of Surfagon on Open Field and Elevated Plus Maze Behavior of Gonadectomized and Non-Gonadectomized Male Rats. Bull Exp Biol Med. 2019 Nov;168(1):52-54. DOI:10.1007/s10517-019-04644-4
[3] Kraevskiy A Y, et al. Surfagon and Ketaprofen for increasing fertility and preventing embryonic death in cows after insemination AY[J]. Ukrainian Journal of Ecology, 2020, 10(4): 159-164.
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