| Identification | Back Directory | [Name]
[des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate | [CAS]
52435-06-0 | [Synonyms]
AY25 AY-25 LRH-A AY 25 LHRH-A LHRH-A2 TAP 127 AY-25205 Wy-18481 leuprolideIS [D-Ala6]des-Gly10-GnRH ethylamide (Des-Gly10,D-Ala6,proethylamide9)-LRH [des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate luteinizing hormone releasing hormone (D-Ala^<6^>) analog [D-Ala6]des-Gly10-gonadotropin releasing hormone ethylamide [des-gly10, d-ala6]-lh-rh ethylamide acetate hydrate USP/EP/BP 5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-D-Ala-L-Leu-L-Arg-L-Pro-NHEt 1-9-Luteinizing hormone-releasing factor (swine), 6-D-alanine-9-(N-ethyl-L-prolinamide)- (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide | [Molecular Formula]
C56H78N16O12 | [MOL File]
52435-06-0.mol | [Molecular Weight]
1167.32 |
| Chemical Properties | Back Directory | [density ]
1.48±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
9.82±0.15(Predicted) | [color ]
White to off-white | [Sequence]
{Pyr}-His-Trp-Ser-Tyr-{d-Ala}-Leu-Arg-Pro-NHEt |
| Hazard Information | Back Directory | [Chemical Properties]
Off-white freeze-dried powder. Soluble in water and saline. | [Uses]
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (Surfagon, Mwt 1167.34 Da) is an agonist of gonadotropin-releasing hormone (GnRH). (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH can be used as an internal standard for the LC-MS analysis of leuprorelide acetate. (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH has potential applications in biochemical analysis and fertility[1][2][3]. | [in vivo]
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (2 μg/kg; i.p.; single dose) significantly increases anxiety behavior in adult male rats with and without gonadectomy[2].
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (50 μg; single dose) improves the fertility of cows after fertilization and prevents embryo death when combined with Ainil (30 μL/kg)[3].
| [References]
[1] Wan B, et al. Polymer source affects in vitro-in vivo correlation of leuprolide acetate PLGA microspheres. Int J Pharm. 2022 Sep 25;625:122032. DOI:10.1016/j.ijpharm.2022.122032 [2] Masalova OO, et al. Effect of Surfagon on Open Field and Elevated Plus Maze Behavior of Gonadectomized and Non-Gonadectomized Male Rats. Bull Exp Biol Med. 2019 Nov;168(1):52-54. DOI:10.1007/s10517-019-04644-4 [3] Kraevskiy A Y, et al. Surfagon and Ketaprofen for increasing fertility and preventing embryonic death in cows after insemination AY[J]. Ukrainian Journal of Ecology, 2020, 10(4): 159-164. |
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