| Identification | Back Directory | [Name]
Propargyl-PEG2- acrylate | [CAS]
52436-42-7 | [Synonyms]
Alkyne-PEG2-AC
PROPARGYL-PEG2-AC
Propargyl-PEG1-acrylate
Acrylate-PEG1-Propargyl
Propargyl-PEG2- acrylate
2-Propenoic acid, 2-(2-propyn-1-yloxy)ethyl ester | [Molecular Formula]
C8H10O3 | [MDL Number]
MFCD24539475 | [MOL File]
52436-42-7.mol | [Molecular Weight]
154.16 |
| Hazard Information | Back Directory | [Uses]
Propargyl-PEG1-acrylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG1-acrylate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [Biological Activity]
Propargyl-PEG1-acrylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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