| Identification | Back Directory | [Name]
8-Methyl-1,2,3,4-tetrahydroquinoline | [CAS]
52601-70-4 | [Synonyms]
AKOS B016010
AKOS BB-9798
ART-CHEM-BB B016010
8-METHYL-1,2,3,4-TETRAHYDROQUINOLINE
Quinoline, 1,2,3,4-tetrahydro-8-methyl-
8-Methyl-1,2,3,4-tetrahydroquinoline 98% | [Molecular Formula]
C10H13N | [MDL Number]
MFCD00218100 | [MOL File]
52601-70-4.mol | [Molecular Weight]
147.22 |
| Chemical Properties | Back Directory | [Boiling point ]
255 °C | [density ]
0.990±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
liquid | [pka]
5.01±0.20(Predicted) | [color ]
Light brown | [CAS DataBase Reference]
52601-70-4 |
| Hazard Information | Back Directory | [Uses]
8-Methyl-1,2,3,4-tetrahydroquinoline is a useful reagent for template-directed meta-C-H activation. | [Definition]
ChEBI: 8-Methyl-1,2,3,4-tetrahydroquinoline is a member of quinolines. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 25, p. 463, 1960 DOI: 10.1021/jo01073a611 | [Synthesis]
The general procedure for the synthesis of 8-methyl-1,2,3,4-tetrahydroquinoline from 8-methylquinoline is as follows: unlike the Suzuki-Miyaura coupling reaction, the Pd-pol catalyst exhibits truly non-homogeneous catalytic properties for the reduction of nitroaromatics in the aqueous phase (see Table 2) [46]. In addition, the catalyst can be used for the selective hydrogenation of quinoline derivatives in aqueous-phase media at a pressure of 10 bar H2 at a reaction temperature of 80 °C (cf. Table 3) [47] or at 60 °C with NaBH4 as a hydrogen source (cf. Table 4) [48]. | [References]
[1] Molecules, 2015, vol. 20, # 10, p. 18661 - 18684
[2] Advanced Synthesis and Catalysis, 2017, vol. 359, # 6, p. 933 - 940
[3] Chemical Communications, 2013, vol. 49, # 63, p. 7052 - 7054
[4] Advanced Synthesis and Catalysis, 2016, vol. 358, # 19, p. 3039 - 3045
[5] Patent: CN106831565, 2017, A. Location in patent: Paragraph 0079; 0080; 0081; 0082 |
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