| Identification | Back Directory | [Name]
1-O-HEXADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE | [CAS]
52691-62-0 | [Synonyms]
LYSO-PAF16
1-hexadecyl
C16 LYSO PAF
LYSO-PAF (C16)
Lyso-PAF (C16),98%
LYSO-PLATELET ACTIVATING FACTOR
LYSO-PLATELET ACTIVATING FACTOR-16
LYSO-PLATELET ACTIVATING FACTOR (C16)
1-O-Alkyl-sn-glycero-3-phosphocholine
1-hexadecyl-sn-glycero-3-phosphocholine
1-O-PALMITYL-SN-GLYCERO-3-PHOSPHOCHOLINE
1-O-HEXADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE
3-sn-Lysophosphatidylcholine, 1-hexadecyl
1-O-HEXADECYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE
1-O-HEXADECYL-SN-GLYCERYL-3-PHOSPHORYLCHOLINE
L-ALPHA-PHOSPHATIDYLCHOLINE-GAMMA-O-HEXADECYL
GAMMA-O-HEXADECYL L-A-LYSOPHOSPHATIDYLCHOLINE
1-O-hexadecyl-2-lyso-glycero-3-phosphorylcholine
L-A-LYSOPHOSPHATIDYLCHOLINE, GAMMA-O-*HE XADECYL
L-ALPHA-LYSOPHOSPHATIDYLCHOLINE, GAMMA-O-HEXADECYL
1-O-HEXADECYL-2-HYDROXY-SN-GLYCERO-3-PHOSPHOCHOLINE
L -ALPHA-LYSOPHOSPHATIDYL- CHOLINE-GAMMA-O-HEXADECYL 99%
γ-O-Alkyl-L-α-lysophosphatidylcholine from bovine heart
LYSO PAF[C16] (L-A-LYSOPHOSPHATIDYLCHOLI NBE, GAMMA-O-HEXADECYL)
1-O-Alkyl-sn-glycero-3-phosphocholine, Lyso-platelet activating factor
1-Hexadecyl-sn-glycero-3-phosphocholine, 3-sn-Lysophosphatidylcholine, 1-hexadecyl, Lyso-PAF-C16, Lyso-platelet activating factor | [Molecular Formula]
C24H52NO6P | [MDL Number]
MFCD00042932 | [MOL File]
52691-62-0.mol | [Molecular Weight]
481.65 |
| Chemical Properties | Back Directory | [Appearance]
white solid | [Melting point ]
>240 °C | [storage temp. ]
−20°C
| [solubility ]
DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 10 mg/ml; Water: 20 mg/ml | [form ]
A lyophilized powder | [pka]
1.209±0.50(predicted) | [color ]
White to off-white | [biological source]
synthetic | [CAS DataBase Reference]
52691-62-0 |
| Hazard Information | Back Directory | [Chemical Properties]
white solid | [Uses]
Lyso-PAF C-16 can be formed by either the action of PAF-AH on PAF C-16, or by the action of a CoA-independent transacylase on 1-O-hexadecyl-2-acyl-glycerophosphocholine. Lyso-PAF C-16 is a substrate for either PAF C-16 formation by the remodeling pathway or selective acylation with arachidonic acid by a CoA-independent transacylase. | [Description]
Lyso-PAF C-16 can be formed by either the action of PAF-AH on PAF C-16, or by the action of a CoA-independent transacylase on 1-O-hexadecyl-2-acyl-glycerophosphocholine. Lyso-PAF C-16 is a substrate for either PAF C-16 formation by the remodeling pathway or selective acylation with arachidonic acid by a CoA-independent transacylase. | [Definition]
ChEBI: Lysophosphatidylcholine O-16:0/0:0 is a lysophosphatidylcholine O-16:0e in which the hexadecyl group at C-1 contains 16 carbons of which none are unsaturated. It has a role as a metabolite. It is a lysophosphatidylcholine O-16:0 and a 1-alkyl-sn-glycero-3-phosphocholine. | [References]
[1] D M STAFFORINI L W T. Human plasma platelet-activating factor acetylhydrolase.[J]. Methods in molecular biology, 1999, 109: 49-58. DOI: 10.1385/1-59259-581-2:49
[2] Y. UEMURA F S T Lee. A coenzyme A-independent transacylase is linked to the formation of platelet-activating factor (PAF) by generating the lyso-PAF intermediate in the remodeling pathway.[J]. The Journal of Biological Chemistry, 1991, 50 1: 8268-8272. DOI: 10.1016/s0021-9258(18)92972-8
[3] M E VENABLE. Conversion of 1-O-[3H]alkyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine to lyso platelet-activating factor by the CoA-independent transacylase in membrane fractions of human neutrophils.[J]. The Journal of Biological Chemistry, 1991, 266 28: 18691-18698.
[4] K DEGUCHI A D S Murashima. [Platelet activating factor].[J]. Nihon rinsho. Japanese journal of clinical medicine, 1987, 45 5: 1115-1126.
[5] M. VENABLE. Enzymatic studies of lyso platelet-activating factor acylation in human neutrophils and changes upon stimulation.[J]. The Journal of Biological Chemistry, 1993, 49 1: 7965-7975. DOI: 10.1016/s0021-9258(18)53052-0 |
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