| Identification | Back Directory | [Name]
4-BROMO-5-FLUORO-2-METHYLANILINE | [CAS]
52723-82-7 | [Synonyms]
4-Bromo-5-fluoro-o-toluidine
Methyl-4-bromo-5-fluoroaniline
2-Amino-4-fluoro-5-bromotoluene
2-Methyl-4-bromo-5-fluoroaniline
4-BROMO-5-FLUORO-2-METHYLANILINE
4-bromo-5-fluoro-2-methylbenzenamine
Benzenamine, 4-bromo-5-fluoro-2-methyl- | [Molecular Formula]
C7H7BrFN | [MDL Number]
MFCD04973753 | [MOL File]
52723-82-7.mol | [Molecular Weight]
204.04 |
| Chemical Properties | Back Directory | [Melting point ]
77-80°C | [Boiling point ]
245℃ | [density ]
1.589 | [Fp ]
102℃ | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
powder | [pka]
2.73±0.10(Predicted) | [color ]
Creamy beige | [InChI]
InChI=1S/C7H7BrFN/c1-4-2-5(8)6(9)3-7(4)10/h2-3H,10H2,1H3 | [InChIKey]
BRAZFTXACIZDRP-UHFFFAOYSA-N | [SMILES]
C1(N)=CC(F)=C(Br)C=C1C |
| Hazard Information | Back Directory | [Chemical Properties]
Type of white solid | [Synthesis]
General procedure for the synthesis of 4-bromo-5-fluoro-2-methylaniline from 5-fluoro-2-methylaniline: In a dry reaction flask, N-bromosuccinimide (NBS, 14.22 g, 80 mmol), 5-fluoro-2-methylaniline (10 g, 80 mmol), and N,N-dimethylformamide (DMF, 200 mL) were added in sequence. The reaction mixture was stirred at 25°C for 12 hours. Upon completion of the reaction, the mixture was slowly poured into ice water and a solid was precipitated. The solid was collected by filtration and washed with cold water to afford 4-bromo-5-fluoro-2-methylaniline (13 g, 71% yield) as a yellow solid. Product mass spectral data: LC-MS m/z 204 ([M + H]+), retention time 1.68 min. | [References]
[1] Patent: WO2016/203401, 2016, A1. Location in patent: Page/Page column 72
[2] Patent: WO2018/104766, 2018, A1. Location in patent: Page/Page column 72 |
| Questions And Answer | Back Directory | [Application]
Polymers of aniline and aniline derivatives (such as 4-bromo-5-fluoro-2-methylaniline) can be used to manufacture thermoelectric materials. These materials are energy conversion materials that rely on temperature difference to drive the movement of charge carriers inside the material to achieve direct conversion of thermal energy and electrical energy. They are characterized by easy synthesis, tunable structure, electrical conductivity, good solubility, and low thermal conductivity. |
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