| Identification | Back Directory | [Name]
2-Propen-1-one, 1-phenyl-3-(2-pyridinyl)- | [CAS]
5325-66-6 | [Synonyms]
Tubulin polymerization-IN-75
2-Propen-1-one, 1-phenyl-3-(2-pyridinyl)- | [Molecular Formula]
C14H11NO | [MOL File]
5325-66-6.mol | [Molecular Weight]
209.24 |
| Chemical Properties | Back Directory | [Melting point ]
63-64 °C(Solv: ligroine (8032-32-4)) | [Boiling point ]
360.9±34.0 °C(Predicted) | [density ]
1.143±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.21±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Tubulin polymerization-IN-75 (Compound 6) is an inhibitor for tubulin polymerization with an IC50 of 30 μM. Tubulin polymerization-IN-75 inhibits the proliferation of cancer cell Huh7 and 293T with IC50 of 14.3 μM and 13.8 μM[1]. | [References]
[1] Kim DY, et al., Design and biological evaluation of novel tubulin inhibitors as antimitotic agents using a pharmacophore binding model with tubulin. J Med Chem. 2006 Sep 21;49(19):5664-70. DOI:10.1021/jm050761i |
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