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532932-99-3

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532932-99-3 Structure

532932-99-3 Structure
IdentificationBack Directory
[Name]

(ALA11,D-LEU15)-OREXIN B (HUMAN)
[CAS]

532932-99-3
[Synonyms]

[ALA11,D-LEU15]-OREXIN B
M.W. 2857.28 C120H206N44O35S
(ALA11,D-LEU15)-OREXIN B (HUMAN)
ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-ALA-GLN-ARG-LEU-D-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2
H-ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-ALA-GLN-ARG-LEU-D-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2
(Ala11,D-Leu15)-Orexin B (human) trifluoroacetate salt H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Ala-Gln-Arg-Leu-D-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2 trifluoroacetate salt
L-Arginyl-L-serylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-alanyl-L-glutaminyl-L-arginyl-L-leucyl-D-leucyl-L-glutaminyl-L-alanyl-L-serylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl-L-methioninamide
L-Methioninamide, L-arginyl-L-serylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-alanyl-L-glutaminyl-L-arginyl-L-leucyl-D-leucyl-L-glutaminyl-L-alanyl-L-serylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl-
[Molecular Formula]

C120H206N44O35S
[MDL Number]

MFCD06798320
[MOL File]

532932-99-3.mol
[Molecular Weight]

2857.26
Chemical PropertiesBack Directory
[storage temp. ]

Desiccate at -20°C
[form ]

Powder
[color ]

White to off-white
[Water Solubility ]

Soluble to 0.30 mg/ml in water
[Sequence]

Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Ala-Gln-Arg-Leu-{dLeu}-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
Hazard InformationBack Directory
[Uses]

[Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) shows a 400-fold selectivity for the OX2 (EC50=0.13 nM) over OX1 (52 nM)[1].
[IC 50]

OX2: 0.13 nM (EC50); OX1: 52 nM (EC50)
[storage]

Desiccate at -20°C
[References]

[1] Asahi S, et al. Development of an orexin-2 receptor selective agonist, [Ala(11), D-Leu(15)]orexin-B. Bioorg Med Chem Lett. 2003;13(1):111-113. DOI:10.1016/s0960-894x(02)00851-x
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