| Identification | Back Directory | [Name]
6,6'-Dichloro-2,2'-bipyridine | [CAS]
53344-72-2 | [Synonyms]
2,2'-Bi(6-chloropyridine)
6,6'-Dichloro-2,2'-bipyridine
2,2'-Bipyridine, 6,6'-dichloro-
2-chloro-6-(6-chloropyridin-2-yl)pyridine | [Molecular Formula]
C10H6Cl2N2 | [MDL Number]
MFCD11042483 | [MOL File]
53344-72-2.mol | [Molecular Weight]
225.07 |
| Chemical Properties | Back Directory | [Melting point ]
220℃ (benzene ) | [Boiling point ]
354.7±37.0 °C(Predicted) | [density ]
1.363±0.06 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
Inert atmosphere,Room Temperature | [pka]
-0.40±0.10(Predicted) | [Appearance]
Off-white to pink Solid |
| Hazard Information | Back Directory | [Synthesis]
The synthesis of 6,6'-dichloro-2,2'-bipyridine (52a) was achieved by reacting a mixture of BuLi/Me2N(CH2)2OLi with 2-chloropyridine as starting material. This mixture served as a base for selective lithiation of the C-6 region (Scheme 23). The 6-lithium-2-chloropyridine generated during the reaction was further reacted with the starting material 2-chloropyridine to produce the target coupling product 52a in 47% yield. | [References]
[1] Organic Letters, 2000, vol. 2, # 6, p. 803 - 805
[2] Patent: US2010/298562, 2010, A1. Location in patent: Page/Page column 34
[3] Organic Letters, 2000, vol. 2, # 6, p. 803 - 805
[4] Phosphorus and Sulfur and the Related Elements, 1987, vol. 34, p. 123 - 132
[5] Patent: CN107935919, 2018, A. Location in patent: Paragraph 0049; 0051 |
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