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53552-05-9

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53552-05-9 Structure

53552-05-9 Structure
IdentificationBack Directory
[Name]

(-)-BICUCULLINE METHOCHLORIDE
[CAS]

53552-05-9
[Synonyms]

l-Bicuculline methochloride
(-)-BICUCULLINE METHOCHLORIDE
(?)-Bicuculline methochloride
[R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium chloride
[R-(R*,S*)]-5-(6,8-DIHYDRO-8-OXOFURO[3,4-E]-1,3-BENZODIOXOL-6-YL)-5,6,7,8-TETRAHYDRO-6,6-DIMETHYL-1,3-DIOXOLO[4,5-G]ISOQUINOLINIUM CHLORIDE
1,3-Dioxolo[4,5-g]isoquinolinium,5-[(6S)-6,8-dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-,chloride (1:1), (5R)-
[Molecular Formula]

C21H20ClNO6
[MDL Number]

MFCD00078981
[MOL File]

53552-05-9.mol
[Molecular Weight]

417.84
Chemical PropertiesBack Directory
[storage temp. ]

Store at RT
[solubility ]

DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
[form ]

Powder
[Water Solubility ]

Soluble to 100 mM in water
Safety DataBack Directory
[Symbol(GHS) ]

Environment (GHS09)Skull and Crossbones (GHS06)
GHS09,GHS06
[Signal word ]

Danger
[Hazard statements ]

H300-H400-H331-H311
[Precautionary statements ]

P264-P270-P301+P310-P321-P330-P405-P501-P261-P271-P304+P340-P311-P321-P403+P233-P405-P501-P280-P302+P352-P312-P322-P361-P363-P405-P501-P273-P391-P501
Hazard InformationBack Directory
[Uses]

(-)-Bicuculline Methochloride is a GABA receptor inhibitor. Convulsant.
[Biological Activity]

Methochloride salt of (+)-bicuculline ([R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one ). Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.
[in vivo]

(+)-Bicuculline methochloride (0.6 nmol/rat) attenuates the antiallodynic effect of Neurotropin[2].

Animal Model:Rat L5-SNL model[2]
Dosage:0.6 nmol/rat
Administration:Intrathecal injection, 5 minutes before administration of Neurotropin (100 NU/kg, i.v.)
Result:Attenuated the antiallodynic effect of Neurotropin.
[target]

GABA Receptor
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