| Identification | Back Directory | [Name]
4-(PIPERIDIN-4-YL)-MORPHOLINE | [CAS]
53617-35-9 | [Synonyms]
AKOS BB-9182
TIMTEC-BB SBB010091
CHEMBRDG-BB 4004473
4-MORPHOLINOPIPERIDINE
4-Morpholino-piperidin
4-(Morpholin-4-yl)piperidine
4-(4-Piperidinyl) morpholine
Morpholine,4-(4-piperidinyl)-
4-(PIPERIDIN-4-YL)-MORPHOLINE
4-piperidin-4-ylmorpholine 2HCl
4-(PIPERIDIN-4-YL)-MORPHOLINE >98%
4-MORPHOLINO-PIPERDINEDIHYDROCHLORIDE
4-piperidin-4-ylmorpholine(SALTDATA: 2HCl) | [EINECS(EC#)]
1592732-453-0 | [Molecular Formula]
C9H18N2O | [MDL Number]
MFCD03274733 | [MOL File]
53617-35-9.mol | [Molecular Weight]
170.25 |
| Chemical Properties | Back Directory | [Melting point ]
40-43 °C(lit.)
| [Boiling point ]
100-115 °C0.15-0.20 mm Hg(lit.)
| [density ]
1.033±0.06 g/cm3(Predicted) | [vapor pressure ]
0.63-4.58Pa at 25-45℃ | [Fp ]
>230 °F
| [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
Solid | [pka]
10.21±0.10(Predicted) | [Appearance]
Colorless to off-white Solid | [InChI]
InChI=1S/C9H18N2O/c1-3-10-4-2-9(1)11-5-7-12-8-6-11/h9-10H,1-8H2 | [InChIKey]
YYBXNWIRMJXEQJ-UHFFFAOYSA-N | [SMILES]
N1(C2CCNCC2)CCOCC1 | [LogP]
0.3 at 25℃ and pH11 | [Dissociation constant]
5.44-10.1 at 20℃ |
| Hazard Information | Back Directory | [Uses]
Reactant for synthesis of:
- Selective adenosine A2A receptor antagonists
- Antidepressents
- Small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells
- Orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation
- Quinoline derivatives with antimicrobial activity
- Antimalarials
| [Synthesis]
General procedure for the synthesis of 4-(4-piperidinyl)morpholine from N-benzyl-4-(4-morpholinyl)piperidine: 41.59 g (0.16 mol) of N-benzyl-4-(4-morpholinyl)piperidine was dissolved in 400 mL of methanol, and 5.2 g of 10% palladium/carbon catalyst was added. The hydrogenation reaction was carried out at room temperature for 18 hours at 50 psi hydrogen pressure. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated. A colorless oily substance was obtained, which was left to crystallize. The yield was 25.29 g with 93% yield. | [References]
[1] Patent: US2008/45705, 2008, A1. Location in patent: Page/Page column 10-11
[2] Patent: US2003/69297, 2003, A1
[3] Patent: US2003/125370, 2003, A1 |
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