| Identification | Back Directory | [Name]
15-deoxy-Δ12,14-Prostaglandin J2 Glutathione | [CAS]
537695-15-1 | [Synonyms]
PJVSKAKTGJJITI-YPYHUWNQSA-N
15-deoxy-Δ12,14-Prostaglandin J2 Glutathione | [Molecular Formula]
C30H45N3O9S | [MOL File]
537695-15-1.mol | [Molecular Weight]
623.758 |
| Hazard Information | Back Directory | [Description]
15-deoxy-Δ12,14-Prostaglandin J2 Glutathione (15-deoxy-Δ12,14-PGJ2 Glutathione) is a non-enzymatic adduct formed from 15-deoxy-Δ12,14-PGJ2 and glutathione.1,2,3 The biological properties of this compound have not been characterized. | [Definition]
ChEBI: 15-deoxy-goyazensolide is a terpene lactone. | [References]
1. Cox, B., Murphey, L.J., Zackert, W.E., et al. Human colorectal cancer cells efficiently conjugate the cyclopentenone prostaglandin, prostaglandin J2, to glutathione Biochim. Biophys. Acta 1584,37-45(2002).
2. Brunoldi, E.M., Zanoni, G., Vidari, G., et al. Cyclopentenone prostaglandin, 15-deoxy-Δ12,14-PGJ2, is metabolized by HepG2 cells via conjugation with glutathione Chem. Res. Toxicol. 20,1528-1535(2007).
3. Paumi, C.M., Smitherman, P.K., Townsend, A.J., et al. Glutathione S-transferases (GSTs) inhibit transcriptional activation by the peroxisomal proliferator-activated receptor γ (PPARγ) ligand, 15-deoxy-Δ12,14 prostaglandin J2 (15-d-PGJ2). Biochemistry 43(8),2345-2352(2004). |
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