| Identification | Back Directory | [Name]
A-350619 HYDROCHLORIDE | [CAS]
538368-27-3 | [Synonyms]
A-350619
2-Propenamide, 3-[2-[(4-chlorophenyl)thio]phenyl]-N-[4-(dimethylamino)butyl]-
(E)-3-[2-(4-chlorophenyl)sulfanylphenyl]-N-[4-(dimethylamino)butyl]prop-2-enamide
3-[2-[(4-Chlorophenyl)thiophenyl]-N-[4-(dimethylamino)butyl]-2-propenamidehydrochloride | [Molecular Formula]
C21H25ClN2OS | [MDL Number]
MFCD09971131 | [MOL File]
538368-27-3.mol | [Molecular Weight]
388.95 |
| Chemical Properties | Back Directory | [Melting point ]
175.2-176.7 °C | [Boiling point ]
567.0±50.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
H2O: 23 mg/mL | [form ]
solid | [pka]
15.14±0.46(Predicted) | [color ]
white | [Water Solubility ]
H2O: 23mg/mL |
| Hazard Information | Back Directory | [Uses]
A-350619 relaxes cavernosum tissue strips in a dose dependent manner with EC50 of 80 μMM. Because A-350619 at 1 μMmol/kg induces penile erection in a conscious r at model, it may be useful as an alternate method of enhancing the effect of nitric oxide for the treatment of sexual dysfunction. | [Biological Activity]
Activator of soluble guanylyl cyclase (sGC). Activates basal sGC and synergistically activates sGC in the presence of NO. Relaxes cavernosum smooth muscle in vitro and induces penile erections in rats in vivo . |
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