| Identification | Back Directory | [Name]
6,9-DICHLORO-1,2,3,4-TETRAHYDROACRIDINE | [CAS]
5396-25-8 | [Synonyms]
6,9-DICHLORO-1,2,3,4-TETRAHYDROACRIDINE
ACRIDINE, 6,9-DICHLORO-1,2,3,4-TETRAHYDRO-
6-Chloro-9-Chloro-1,2,3,4-Tetrahydroacridine | [Molecular Formula]
C13H11Cl2N | [MDL Number]
MFCD11849267 | [MOL File]
5396-25-8.mol | [Molecular Weight]
252.14 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 5 mg/ml,DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml,DMSO: 1 mg/ml,Ethanol: 1 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Uses]
6,9-Dichloro-1,2,3,4-tetrahydroacridine (compound 26) is an intermediate for the synthesis of acetylcholinesterase (AChE) inhibitors, which can be used in the study of Alzheimer's disease[1]. | [Biological Activity]
6,9-Dichloro-1,2,3,4-tetrahydroacridine is a synthetic intermediate in the synthesis of tacrine-based acetylcholinesterase (AChE) inhibitors.1 It is also an intermediate in the synthesis of multifunctional tacrine hybrids that possess radical scavenging, amyloid-β aggregation inhibitory, and/or β-secretase 1 (BACE1) inhibitory activities in addition to their activity as AChE inhibitors.2,3 | [References]
1.Recanatini, M., Cavalli, A., Belluti, F., et al.SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: Synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analoguesJ. Med. Chem.43(10)2007-2018(2000)
2.Digiacomo, M., Chen, Z., Wang, S., et al.Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of ADBioorg. Med. Chem. Lett.25(4)807-810(2015)
3.Li, S.Y., Jiang, N., Xie, S.S., et al.Design, synthesis and evaluation of novel tacrine-rhein hybrids as multifunctional agents for the treatment of Alzheimer's diseaseOrg. Biomol. Chem.12(5)801-814(2014)
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