| Identification | Back Directory | [Name]
Benzeneacetonitrile, 4-(2-benzoxazolyl)-2-methoxy- | [CAS]
540496-84-2 | [Synonyms]
BOMA
Benzeneacetonitrile, 4-(2-benzoxazolyl)-2-methoxy- | [Molecular Formula]
C16H12N2O2 | [MOL File]
540496-84-2.mol | [Molecular Weight]
264.28 |
| Hazard Information | Back Directory | [Uses]
BOMA (Compound 7) is a potent and selective metabotropic glutamate receptor 5 (mGluR 5) antagonist with an IC50 value of 3 nM and an Ki value of 3 nM. BOMA is promising for research of various pain states, including acute, persistent and chronic pain, inflammatory pain and neuropathic pain[1]. | [IC 50]
mGluR5: 3 nM (IC50) | [References]
[1] Wang B, et al. Discovery of novel modulators of metabotropic glutamate receptor subtype-5. Bioorg Med Chem. 2004 Jan 2;12(1):17-21. DOI:10.1016/j.bmc.2003.10.021 |
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