| Identification | Back Directory | [Name]
2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE) | [CAS]
54135-60-3 | [Synonyms]
M50054 2,2'-METHYLENEBIS(1,3-CYCLOHEXANEDIONE) 2,2-METHYLENEBIS-(1,3-CYCLOHEXANEDIONE) 2,2'-METHYLENE BIS CYCLOHEXANE-1,3-DIONE 1,3-Cyclohexanedione, 2,2'-methylenebis- Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem 2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione | [EINECS(EC#)]
258-989-1 | [Molecular Formula]
C13H16O4 | [MDL Number]
MFCD00192291 | [MOL File]
54135-60-3.mol | [Molecular Weight]
236.26 |
| Chemical Properties | Back Directory | [Melting point ]
132.5-133.5 °C | [Boiling point ]
461.2±40.0 °C(Predicted) | [density ]
1.227±0.06 g/cm3(Predicted) | [storage temp. ]
+2C to +8C | [solubility ]
Soluble in DMSO or ethanol | [form ]
Off-white solid | [pka]
4.87±0.25(Predicted) | [color ]
off-white | [Sensitive ]
Light Sensitive |
| Hazard Information | Back Directory | [Uses]
A cell-permeable inhibitor of apoptosis induction. Inhibits caspase-3 activation but does not directly inhibit caspase-3 even at 1 mg/ml. | [Definition]
ChEBI: 2-[(2,6-dioxocyclohexyl)methyl]cyclohexane-1,3-dione is a beta-diketone. | [Biological Activity]
m50054, 2,2'-methylenebis (1,3-cyclohexanedione), is a novel inhibitor of apoptosis. [1]in human fas-expressing wc8 cells, m50054 inhibited apoptosis by soluble human fas ligand in vitro cell death assay. m50054 inhibited the apoptotic u937 cell death which is a human monocytic leukemic cell line, induced by anticancer agents such as etoposide. m50054 inhibited apoptotic characters such as dna phosphatidylserine and fragmentation exposure in these cells. these anti-apoptotic effects were dependent on inhibition of caspase-3 activation. additionally, m50054 significantly inhibited anti-fas-antibody-induced elevation of plasma aspartate aminotransferase and alanine aminotransferase. alopecia (hair loss) symptoms were also significantly improved with topical treatment with m50054. m50054 inhibits apoptosis induced by a variety of stimuli via inhibition of caspase-3 activation, and may thus be effective for hepatitis and chemotherapy-induced alopecia. [1] | [in vivo]
M50054 (10-300 mg/kg; oral administration 30 min before anti-Fas antibody injection) inhibits the elevation of alanine aminotransferase and aspartate aminotransferase in a dose-dependent manner[1].
M50054 (topical treatment; given daily beginning on day 5 after birth and ending on day 14) significantly improves alopecia (hair loss) symptoms[1]. | Animal Model: | Female BALB/c mice[1] | | Dosage: | 10, 30, 100 or 300 mg/kg | | Administration: | Orally administered in a volume of 10 mL/kg | | Result: | Inhibited the elevation of alanine aminotransferase and aspartate aminotransferase in a dose-dependent manner.
Significantly improved these parameters at doses of 100 mg/kg and 300 mg/kg.
|
| Animal Model: | Five-day-old SD rats[1] | | Dosage: | | | Administration: | Topically applied to the head and back of 5-day-old rats once daily for 10 days | | Result: | Alopecia scores significantly decreased throughout the entire observation period compared with the control group. |
| [target]
Caspase | [References]
tsuda t, ohmori y, muramatsu h et al. inhibitory effect of m50054, a novel inhibitor of apoptosis, on anti-fas-antibody-induced hepatitis and chemotherapy-induced alopecia.eur j pharmacol. 2001 dec 14;433(1):37-45. |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck Millipore
|
| Tel: |
1-400-889-1988 400-889-1988 |
| Website: |
http://www.merckmillipore.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|