| Identification | Back Directory | [Name]
2-BROMO-5-HYDROXY-3-PICOLINE | [CAS]
54232-03-0 | [Synonyms]
6-bromo-5-methylpyridin-3-ol
2-BROMO-5-HYDROXY-3-PICOLINE
3-Pyridinol,6-bromo-5-methyl-
6-chloro-5-Methylpyridin-3-ol
6-chloro-5-Methyl-3-Pyridinol
2-Chloro-5-hydroxy-3-methylpyrdine
2-Chloro-5-hydroxy-3-methylpyridine
2-Chloro-3-methyl-5-hydroxypyridine
6-Chloro-5-methyl-3-hydroxy-pyridine | [Molecular Formula]
C6H6BrNO | [MDL Number]
MFCD09839267 | [MOL File]
54232-03-0.mol | [Molecular Weight]
188.022 |
| Chemical Properties | Back Directory | [Boiling point ]
353.0±37.0 °C(Predicted) | [density ]
1.313±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [pka]
8.81±0.10(Predicted) | [Appearance]
White to light yellow Solid | [CAS DataBase Reference]
54232-03-0 |
| Hazard Information | Back Directory | [Synthesis]
To a stirred solution of methanol (15 mL) was added potassium carbonate (1.10 g, 0.0081 mol) as 6-chloro-5-methylpyridin-3-yl acetate (750 mg, 0.004 mol) at room temperature. The reaction mixture was stirred continuously at ambient temperature for 1 hour. Subsequently, the solvent was removed by concentration under reduced pressure and the residue was diluted with a minimal amount of water and neutralized with 1N hydrochloric acid (15 mL). After neutralization was complete, the solution was extracted using ethyl acetate (2 x 100 mL). The combined organic layers were washed with brine, dried over anhydrous sodium sulfate and concentrated to give 6-chloro-5-methylpyridin-3-ol as an off-white solid (500 mg, 89% yield). Mass spectrometry analysis showed m/z = 143.01 [M + H]+. 1H-NMR (300 MHz, DMSO-d6) data were as follows: δ 10.09 (s, 1H), 7.76 (d, J = 3Hz, 1H), 7.18 (d, J = 3.6Hz, 1H), 2.24 (s, 3H). | [References]
[1] Patent: WO2014/138484, 2014, A1. Location in patent: Page/Page column 157
[2] Patent: WO2016/22724, 2016, A1. Location in patent: Page/Page column 297
[3] Patent: US2014/249104, 2014, A1. Location in patent: Page/Page column |
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