| Identification | Back Directory | [Name]
bassianin | [CAS]
54278-73-8 | [Synonyms]
bassianin
3-[(2E,4E,6E)-6,8-Dimethyl-1-oxo-2,4,6-decatrienyl]-1,4-dihydroxy-5-(4-hydroxyphenyl)pyridin-2(1H)-one
2(1H)-Pyridinone, 3-[(2E,4E,6E)-6,8-dimethyl-1-oxo-2,4,6-decatrienyl]-1,4-dihydroxy-5-(4-hydroxyphenyl)- | [Molecular Formula]
C23H25NO5 | [MOL File]
54278-73-8.mol | [Molecular Weight]
395.45 |
| Hazard Information | Back Directory | [Uses]
Bassianin is a compound isolated from fungi that has the activity of inhibiting erythrocyte membrane ATPase and causing cell lysis. Its inhibitory effect on ATPase may be due to membrane disruption. | [Biological Activity]
Bassianin is a fungal metabolite that has been found in Beauveria.1,2 It inhibits Mg2+-, Ca2+-, and Na+/K+-ATPase activities in equine erythrocyte ghosts by 81, 58, and 23%, respectively, when used at a concentration of 200 μg/ml.1 Bassianin is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.91 and 12.12 μM, respectively.2 | [References]
1.Jeffs, L.B., and Khachatourians, G.G.Toxic properties of Beauveria pigments on erythrocyte membranesToxicon.35(8)1351-1356(1997)
2.Arboleda Valencia, J.W., Gaitán Bustamante, A.L., Jiménez, A.V., et al.Cytotoxic activity of fungal metabolites from the pathogenic fungus Beauveria bassiana: An intraspecific evaluation of beauvericin productionCurr. Microbiol.63(3)306-312(2011)
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