| Identification | Back Directory | [Name]
BMS-433771 BIS-HYDROCHLORIDE MONOHYDRATE | [CAS]
543700-67-0 | [Synonyms]
BMS-433771 dihydrochloride hydrate
BMS-433771 BIS-HYDROCHLORIDE MONOHYDRATE
BMS-433771 bis-hydrochloride monohydrate >=98% (HPLC) | [Molecular Formula]
C21H26ClN5O3 | [MOL File]
543700-67-0.mol | [Molecular Weight]
431.92 |
| Hazard Information | Back Directory | [Uses]
BMS-433771 dihydrochloride hydrate is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 dihydrochloride hydrate is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 dihydrochloride hydrate can be used for the research of respiratory tract disease[1][2]. | [in vivo]
BMS-433771 dihydrochloride hydrate (p.o.; 1-200 mg/kg; single or bid 4 days) shows prophylactic efficacy via oral dosing, but has considerable pharmacodynamic differences between the two rodent models[2].
| [References]
[1] Christopher Cianci, et al. Antiviral activity and molecular mechanism of an orally active respiratory syncytial virus fusion inhibitor. J Antimicrob Chemother DOI:10.1093/jac/dkh558
[2] Christopher Cianci, et al. Oral efficacy of a respiratory syncytial virus inhibitor in rodent models of infection. Antimicrob Agents Chemother. 2004 Jul;48(7):2448-54. DOI:10.1128/AAC.48.7.2448-2454.2004 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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