| Identification | Back Directory | [Name]
1-cyclopropyl-3-((1-(4-hydroxybutyl)-1H-benzo[d]imidazol-2-yl)methyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one | [CAS]
543700-68-1 | [Synonyms]
BMS-433771 free base
BMS433771
(BMS-433771)
BMS 433771 free base,BMS433771 free base
2H-Imidazo[4,5-c]pyridin-2-one, 1-cyclopropyl-1,3-dihydro-3-[[1-(4-hydroxybutyl)-1H-benzimidazol-2-yl]methyl]- | [Molecular Formula]
C21H23N5O2 | [MOL File]
543700-68-1.mol | [Molecular Weight]
377.44 |
| Chemical Properties | Back Directory | [Boiling point ]
611.8±45.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
15.11±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
BMS-433771 is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 can be used for the research of respiratory tract disease[1][2]. | [in vivo]
BMS-433771 (p.o.; 1-200 mg/kg; single or bid 4 days) shows prophylactic efficacy via oral dosing, but has considerable pharmacodynamic differences between the two rodent models[2]
. | Animal Model: | rodent models of RSV infection[2]
(cotton rat and mice)
| | Dosage: | 1, 10, and 50 mg/kg (mice); 25, 50, 100, and 200 mg/kg (rat) | | Administration: | oral, single or bid 4 days | | Result: | Had prophylactic efficacy via oral dosing in both animal models.
Showed RSV infection more sensitive to inhibition in the BALB/c mouse host than in the cotton rat.
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| [References]
[1] Christopher Cianci, et al. Antiviral activity and molecular mechanism of an orally active respiratory syncytial virus fusion inhibitor. J Antimicrob Chemother DOI:10.1093/jac/dkh558
[2] Christopher Cianci, et al. Oral efficacy of a respiratory syncytial virus inhibitor in rodent models of infection. Antimicrob Agents Chemother. 2004 Jul;48(7):2448-54. DOI:10.1128/AAC.48.7.2448-2454.2004 |
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