| Identification | Back Directory | [Name]
voacristine | [CAS]
545-84-6 | [Synonyms]
voacristine
COACRISTINE
()-Voacangarine
(?)-Voacangarine
(-)-Voacangarine
(20S)-20-Hydroxy-12-methoxyibogamine-18-carboxylic acid methyl ester
Ibogamine-18-carboxylic acid, 20-hydroxy-12-methoxy-, methyl ester, (20S)- | [Molecular Formula]
C22H28N2O4 | [MOL File]
545-84-6.mol | [Molecular Weight]
384.47 |
| Chemical Properties | Back Directory | [Melting point ]
112-114 °C | [Boiling point ]
542.9±50.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 16 mg/ml; DMSO: 16 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.33 mg/ml | [form ]
A crystalline solid | [pka]
14.94±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
(?)-Voacangarine is an indole alkaloid, which exhibits cytotoxic effects against cancer cells HepG2, A375, MDA-MB-231, SH-SY5Y, and CT26 with IC50 of 5~20 mg/mL. (?)-Voacangarine inhibits the cultivation of Saccharomyces cerevisiae wildtype and repair-deficient mutants[1][2]. | [storage]
Store at -20°C | [References]
[1] Melo AA, et al., Cytostatic, cytotoxic and mutagenic effects of voacristine, an indole alkaloid in wild-type and repair-deficient yeasts. Mutat Res. 1986 Jul;171(1):17-24. DOI:10.1016/0165-1218(86)90004-2 |
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