| Identification | Back Directory | [Name]
6-[(4ar,8as)-octahydroquinolin-1(2H)-ylsulfonyl]-1,2,3,4-tetrahydroquinoline | [CAS]
5455-90-3 | [Synonyms]
6-[(4ar,8as)-octahydroquinolin-1(2H)-ylsulfonyl]-1,2,3,4-tetrahydroquinoline
7-(((4aS,8aR)-octahydroquinolin-1(2H)-yl)sulfonyl)-1,2,3,4-tetrahydroquinoline
Quinoline, decahydro-1-[(1,2,3,4-tetrahydro-6-quinolinyl)sulfonyl]-, trans- (9CI)
6-[[(4aR,8aS)-3,4,4a,5,6,7,8,8a-octahydro-2H-quinolin-1-yl]sulfonyl]-1,2,3,4-tetrahydroquinoline | [Molecular Formula]
C18H26N2O2S | [MDL Number]
MFCD30559255 | [MOL File]
5455-90-3.mol | [Molecular Weight]
334.48 |
| Chemical Properties | Back Directory | [Boiling point ]
517.8±60.0 °C(Predicted) | [density ]
1.196±0.06 g/cm3(Predicted) | [storage temp. ]
+2C to +8C | [solubility ]
DMSO: 50mg/mL | [form ]
White solid | [pka]
1.73±0.20(Predicted) | [color ]
white | [InChI]
1S/C18H26N2O2S/c21-23(22,16-9-10-17-15(13-16)6-3-11-19-17)20-12-4-7-14-5-1-2-8-18(14)20/h9-10,13-14,18-19H,1-8,11-12H2/t14-,18+/m1/s1 | [InChIKey]
LECPJKATPJRAMB-KDOFPFPSSA-N | [SMILES]
[S](=O)(=O)(N3[C@@H]4[C@@H](CCC3)CCCC4)c1cc2c(cc1)NCCC2 |
| Hazard Information | Back Directory | [Uses]
A cell-permeable trans-decahydroquinolinylsulfonamide compound that acts as a potent, selective, and reversible inhibitor of miR-122 (EC50 = 600 nM in Huh7 cells transfected with psiCHECK-miR122 reporter plasmid). Induces a 1,250% increase in the relative luciferase signal that is indicative of strong miRNA-122 inhibition. Displays very little activity towards miR-21. Shown to down regulate the levels of mature miR-122 (by 72%) and the primary miR-122 (down to 3%). Shown to reduce hepatitis C virus (HCV) replication in Huh7 cells (47% reduction at 10 µM).
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. | [Biological Activity]
Cell permeable: yes''Primary Target
miR-122''Reversible: yes |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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